Phenotypes associated with this allele

• Allele Symbol: Nfib^tm2Rmg
• Allele Name: targeted mutation 2, Richard M Gronostajski
• Allele ID: MGI:5052268
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfib^tm2Rmg/Nfib^tm2Rmg	involves: 129S4/SvJae * C57BL/6	MGI:5052292
cn2	Nfib^tm2Rmg/Nfib^tm2Rmg Twist2^tm1(cre)Dor/Twist2^+	involves: 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5052293

Genotype
MGI:5052292

hm1

• Allelic Composition: Nfib^tm2Rmg/Nfib^tm2Rmg
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

respiratory system phenotype ( J:173651 )

N • mice exhibit no overt lung phenotype

Genotype
MGI:5052293

cn2

• Allelic Composition: Nfib^tm2Rmg/Nfib^tm2Rmg; Twist2^tm1(cre)Dor/Twist2⁺
• Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

mortality/aging

perinatal lethality, complete penetrance ( J:173651 )

• despite normal Mendelian ratios at E18.5, no live born mice are recovered at P0

respiratory system

abnormal lung morphology ( J:173651 )

• at E16.5 and E18.5, lungs exhibit aberrant clefts unlike in wild-type mice

enlarged lung ( J:173651 )

abnormal lung development ( J:173651 )

• mice exhibit decreased differentiation of epithelial type I, type II, and ciliated cells compared to in wild-type mice

abnormal lung saccule morphology ( J:173651 )

• at E18.5

abnormal respiratory system physiology ( J:173651 )

• at E16.5 and E18.5, lung cells exhibit increased in epithelial (Ttf1+) and mesenchymal (Ttf1-) cell proliferation compared with cells mice

growth/size/body

enlarged lung ( J:173651 )