About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfibtm2Rmg
targeted mutation 2, Richard M Gronostajski
MGI:5052268
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nfibtm2Rmg/Nfibtm2Rmg involves: 129S4/SvJae * C57BL/6 MGI:5052292
cn2
 		Nfibtm2Rmg/Nfibtm2Rmg
Twist2tm1(cre)Dor/Twist2+ 		involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5052293


Genotype
MGI:5052292
hm1
Allelic
Composition		 Nfibtm2Rmg/Nfibtm2Rmg
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfibtm2Rmg mutation (1 available); any Nfib mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:173651 )
N
• mice exhibit no overt lung phenotype




Genotype
MGI:5052293
cn2
Allelic
Composition		 Nfibtm2Rmg/Nfibtm2Rmg
Twist2tm1(cre)Dor/Twist2+
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfibtm2Rmg mutation (1 available); any Nfib mutation (91 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:173651 )
• despite normal Mendelian ratios at E18.5, no live born mice are recovered at P0

respiratory system
abnormal lung morphology ( J:173651 )
• at E16.5 and E18.5, lungs exhibit aberrant clefts unlike in wild-type mice
abnormal lung development ( J:173651 )
• mice exhibit decreased differentiation of epithelial type I, type II, and ciliated cells compared to in wild-type mice
abnormal respiratory system physiology ( J:173651 )
• at E16.5 and E18.5, lung cells exhibit increased in epithelial (Ttf1+) and mesenchymal (Ttf1-) cell proliferation compared with cells mice

growth/size/body
enlarged lung ( J:173651 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory