About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem
targeted mutation 1, Akiyoshi Uemura
MGI:5052360
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem
Tg(Tek-cre)#Rwng/0 		involves: C57BL/6 * CBA MGI:5052369
cn2
 		Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem
Tg(CAG-cre/Esr1*)1Egwa/0 		involves: C57BL/6 * CBA * DBA/2 MGI:5052370
cn3
 		Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sor+
Tg(Tek-cre)2352Rwng/0 		involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N MGI:5464992


Genotype
MGI:5052369
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem
Tg(Tek-cre)#Rwng/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Tek-cre)#Rwng mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Growth retardation and defective vascular development in Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem Tg(Tek-cre)#Rwng/0 mice

mortality/aging
prenatal lethality, complete penetrance ( J:173943 )
• no neonates are obtained

cardiovascular system

embryo

growth/size/body
embryonic growth retardation ( J:173943 )
• at E10.5




Genotype
MGI:5052370
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem
Tg(CAG-cre/Esr1*)1Egwa/0
Genetic
Background		 involves: C57BL/6 * CBA * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(CAG-cre/Esr1*)1Egwa mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Decreased extraretinal vascular outgrowth in ischemic Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem Tg(CAG-cre/Esr1*)1Egwa/0 retinas

cardiovascular system
abnormal induced retina neovascularization ( J:173943 )
• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice

vision/eye
abnormal induced retina neovascularization ( J:173943 )
• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice




Genotype
MGI:5464992
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sor+
Tg(Tek-cre)2352Rwng/0
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Tek-cre)2352Rwng mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Retardation of retinal vascular growth in Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sor+ Tg(Tek-cre)2352Rwng/0 mice

cardiovascular system
abnormal retina vasculature morphology ( J:191977 )
• retinal vascular growth retardation (reduced radial extension) at P4

vision/eye
abnormal retina vasculature morphology ( J:191977 )
• retinal vascular growth retardation (reduced radial extension) at P4




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory