Phenotypes associated with this allele

• Allele Symbol: Tg(JPH3-GFP,-JPH3*)GXwy
• Allele Name: transgene insertion G, X William Yang
• Allele ID: MGI:5052365
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(JPH3-GFP,-JPH3*)GXwy/0	involves: FVB/N	MGI:5052367

Genotype
MGI:5052367

tg1

• Allelic Composition: Tg(JPH3-GFP,-JPH3*)GXwy/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:174267 )

N • unlike in mice carrying Tg(JPH3*)CXwy no signs of neurodegeneration are detected at 12 months of age

abnormal forebrain morphology ( J:174267 )

abnormal striatum morphology ( J:174267 )

• diffuse accumulation of polyQ nuclear inclusions are detected in the striatum

abnormal hippocampus morphology ( J:174267 )

• progressive formation of polyQ nuclear inclusions between 6 and 14 months of age

abnormal cerebral cortex morphology ( J:174267 )

• progressive formation of polyQ nuclear inclusions between 6 and 14 months of age

neuronal intranuclear inclusions ( J:174267 )

• progressive formation of polyQ nuclear inclusions between 6 and 14 months of age

• inclusions are particularly abundant in the cortex and hippocampus with diffuse accumulation also detected in the striatum

behavior/neurological

abnormal motor learning ( J:174267 )

• impaired motor learning in a rotarod assay at 12 months of age

impaired coordination ( J:174267 )

• at 12 months of age in a rotarod assay

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease-like 2		DOID:0090104	OMIM:606438	J:174267