Phenotypes associated with this allele

• Allele Symbol: Hrh3^tm1.1Jhwa
• Allele Name: targeted mutation 1.1, Joyce J Hwa
• Allele ID: MGI:5052375
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hrh3^tm1.1Jhwa/Hrh3^tm1.1Jhwa	involves: C57BL/6 * C57BL/6NTac	MGI:5056081

Genotype
MGI:5056081

hm1

• Allelic Composition: Hrh3^tm1.1Jhwa/Hrh3^tm1.1Jhwa
• Genetic Background: involves: C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:174155 )

• mice treated with 10 mg/kg proxyfan fail to exhibit improved glucose excursion in a glucose tolerance test unlike similarly treated wild-type mice

• however, mice exhibit normal response to treatment with 30 mg/kg proxyfan and overall glucose excursion analyzed by change of glucose area under the curve

increased circulating glucose level ( J:174155 )

• at 120 minutes in a glucose tolerance test

decreased physiological sensitivity to xenobiotic ( J:174155 )

• mice treated with 10 mg/kg proxyfan fail to exhibit improved glucose excursion in a glucose tolerance test unlike similarly treated wild-type mice

• however, response to treatment with 30 mg/kg is normal