Phenotypes associated with this allele

• Allele Symbol: Tg(HTT*/EGFP)190Nn
• Allele Name: transgene insertion 190, Nobuyuki Nukina
• Allele ID: MGI:5052377
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(HTT*/EGFP)190Nn/0	involves: C57BL/6 * DBA/2	MGI:5052380

Genotype
MGI:5052380

tg1

• Allelic Composition: Tg(HTT*/EGFP)190Nn/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:174269 )

• median survival is 21 weeks

• all die by 25 weeks of age

nervous system

abnormal nervous system morphology ( J:174269 )

• progression of neuropathology is more rapid compared to mice carrying Tg(HTT*/EGFP)150Nn

behavior/neurological

abnormal involuntary movement ( J:174269 )

• chorea-like movements

• show irregular, jerky involuntary head movements at about 8 weeks of age

limb grasping ( J:174269 )

• rare

tremors ( J:174269 )

• fine tremor with onset at about 5-6 weeks of age

ataxia ( J:174269 )

• progressive development of an ataxic gait that is severe and interferes with walking by 16 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:174269