Analysis Tools
endocrine/exocrine glands
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• mice fed a high-fat diet exhibit decreased beta cell proliferation compared with wild-type mice
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• mice fed a high-fat diet exhibit impaired beta cell hyperplasia compared with similarly treated wild-type mice
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• following administration of a glucose bolus, mice exhibit reduced first phase of insulin secretion compared with wild-type mice
• following glucose stimulation in pancreas islets from mice fed a high-fat diet
• however, mice exhibit normal insulin secretion in response to a physiologic (meal) glucose exposure and arginine-stimulated insulin release
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homeostasis/metabolism
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• following administration of a glucose bolus, mice exhibit reduced first phase of insulin secretion compared with wild-type mice
• following glucose stimulation in pancreas islets from mice fed a high-fat diet
• however, mice exhibit normal insulin secretion in response to a physiologic (meal) glucose exposure and arginine-stimulated insulin release
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• during a glucose tolerance test in mice fed a high-fat diet
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cellular
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• mice fed a high-fat diet exhibit decreased beta cell proliferation compared with wild-type mice
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