Phenotypes associated with this allele

• Allele Symbol: Ttk^tm1Katj
• Allele Name: targeted mutation 1, Katja Wassmann
• Allele ID: MGI:5056148
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(Zp3-cre)93Knw/0 Ttk^tm1Katj/Ttk^tm1Katj	involves: 129 * C57BL/6 * C57BL/6J	MGI:5056318

Genotype
MGI:5056318

cn1

• Allelic Composition: Tg(Zp3-cre)93Knw/0; Ttk^tm1Katj/Ttk^tm1Katj
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal female meiosis ( J:173618 )

♀ • oocytes exhibit accelerated anaphase and polar body extrusion compared with wild-type oocytes

♀ • oocytes exhibit defective spindle assembly checkpoint and premature chromosome segregation compared with wild-type oocytes

enhanced polar body extrusion ( J:173618 )

♀ • oocytes exhibit accelerated polar body extrusion compared with wild-type oocytes

abnormal meiotic spindle assembly checkpoint ( J:173618 )

• oocytes exhibit defective spindle assembly checkpoint and premature chromosome segregation compared with wild-type oocytes

reduced female fertility ( J:173618 )

♀ • dramatic

decreased litter size ( J:173618 )

• in female mice

cellular

aneuploidy ( J:173618 )

• 70% of oocytes are aneuploid, with both hyperploidies and hypoploidies, unlike wild-type oocytes

abnormal female meiosis ( J:173618 )

♀ • oocytes exhibit accelerated anaphase and polar body extrusion compared with wild-type oocytes

♀ • oocytes exhibit defective spindle assembly checkpoint and premature chromosome segregation compared with wild-type oocytes

enhanced polar body extrusion ( J:173618 )

♀ • oocytes exhibit accelerated polar body extrusion compared with wild-type oocytes

abnormal meiotic spindle assembly checkpoint ( J:173618 )

• oocytes exhibit defective spindle assembly checkpoint and premature chromosome segregation compared with wild-type oocytes