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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd1d1tm2Aben
targeted mutation 2, Albert Bendelac
MGI:5056289
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cd1d1tm2Aben/Cd1d1tm2Aben B6.129P2-Cd1d1tm2Aben MGI:5056351
hm2
Cd1d1tm2Aben/Cd1d1tm2Aben involves: 129P2/OlaHsd * C57BL/6 MGI:5056352
cx3
Cd1d1tm2Aben/Del(3Cd1d2-Cd1d1)1Crw involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5056353


Genotype
MGI:5056351
hm1
Allelic
Composition
Cd1d1tm2Aben/Cd1d1tm2Aben
Genetic
Background
B6.129P2-Cd1d1tm2Aben
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm2Aben mutation (1 available); any Cd1d1 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit a reduction of Valpha14 NKT cells in the thymus and peripheral tissues such as spleen and liver due to failure of positive selection compared with wild-type mice
• thymocytes and peritoneal macrophages exhibit impaired antigen presentation of alphaGalCer compared with wild-type cells

hematopoietic system
• mice exhibit a reduction of Valpha14 NKT cells in the thymus and peripheral tissues such as spleen and liver due to failure of positive selection compared with wild-type mice




Genotype
MGI:5056352
hm2
Allelic
Composition
Cd1d1tm2Aben/Cd1d1tm2Aben
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm2Aben mutation (1 available); any Cd1d1 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit a reduction of Valpha14 NKT cells in the thymus and peripheral tissues such as spleen and liver due to failure of positive selection compared with wild-type mice
• thymocytes and peritoneal macrophages exhibit impaired antigen presentation of alphaGalCer compared with wild-type cells

hematopoietic system
• mice exhibit a reduction of Valpha14 NKT cells in the thymus and peripheral tissues such as spleen and liver due to failure of positive selection compared with wild-type mice




Genotype
MGI:5056353
cx3
Allelic
Composition
Cd1d1tm2Aben/Del(3Cd1d2-Cd1d1)1Crw
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm2Aben mutation (1 available); any Cd1d1 mutation (35 available)
Del(3Cd1d2-Cd1d1)1Crw mutation (0 available); any Del(3Cd1d2-Cd1d1)1Crw mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• peritoneal macrophages exhibit impaired antigen presentation of alphaGalCer compared with wild-type cells





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory