immune system
• mice exhibit a reduction of Valpha14 NKT cells in the thymus and peripheral tissues such as spleen and liver due to failure of positive selection compared with wild-type mice
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• thymocytes and peritoneal macrophages exhibit impaired antigen presentation of alphaGalCer compared with wild-type cells
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hematopoietic system
• mice exhibit a reduction of Valpha14 NKT cells in the thymus and peripheral tissues such as spleen and liver due to failure of positive selection compared with wild-type mice
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