Phenotypes associated with this allele

• Allele Symbol: Cd79a^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:5056357
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd79a^m1Btlr/Cd79a^m1Btlr	involves: C57BL/6J	MGI:5429186
hm2	Cd79a^m1Btlr/Cd79a^m1Btlr	involves: C57BL/6J * C57BL/10J	MGI:5056370

Genotype
MGI:5429186

hm1

• Allelic Composition: Cd79a^m1Btlr/Cd79a^m1Btlr
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased B cell number ( J:185495 )

• severe B cell deficiency

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

decreased IgM level ( J:185495 )

• following NP-Ficoll immunization

hematopoietic system

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased B cell number ( J:185495 )

• severe B cell deficiency

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

decreased IgM level ( J:185495 )

• following NP-Ficoll immunization

Genotype
MGI:5056370

hm2

• Allelic Composition: Cd79a^m1Btlr/Cd79a^m1Btlr
• Genetic Background: involves: C57BL/6J * C57BL/10J

immune system

decreased B cell number ( J:174338 )

• severely reduced in the blood

abnormal humoral immune response ( J:174338 )

• mice exhibit impaired T-dependent or T-independent humoral immune responses compared with wild-type mice

• after immunization with rSFV-encoded beta-galactosidase or NP-Ficoll, mice fail to mount a B cell response with no production of IgG or IgM unlike wild-type mice

decreased IgG level ( J:174338 )

• after immunization with rSFV-encoded beta-galactosidase or NP-Ficoll, mice fail to mount a B cell response with no production of IgG or IgM unlike wild-type mice

decreased IgM level ( J:174338 )

• after immunization with rSFV-encoded beta-galactosidase or NP-Ficoll, mice fail to mount a B cell response with no production of IgG or IgM unlike wild-type mice

hematopoietic system

decreased B cell number ( J:174338 )

• severely reduced in the blood

decreased IgG level ( J:174338 )

• after immunization with rSFV-encoded beta-galactosidase or NP-Ficoll, mice fail to mount a B cell response with no production of IgG or IgM unlike wild-type mice

decreased IgM level ( J:174338 )

• after immunization with rSFV-encoded beta-galactosidase or NP-Ficoll, mice fail to mount a B cell response with no production of IgG or IgM unlike wild-type mice