All Phenotypes Tubb2b<brdp> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tubb2b^brdp/Tubb2b^brdp	involves: A/J * FVB	MGI:5522833
hm2	Tubb2b^brdp/Tubb2b^brdp	involves: A/J * FVB/N	MGI:5056381
ht3	Tubb2b^brdp/Tubb2b⁺	involves: A/J * CD-1 * FVB/N	MGI:5522835
ht4	Tubb2b^brdp/Tubb2b⁺	involves: A/J * FVB	MGI:5522834
ht5	Tubb2b^brdp/Tubb2b⁺	involves: A/J * FVB/N * ICR	MGI:5522836

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:201099 )

• mice do not survive birth

respiratory system

respiratory distress ( J:201099 )

• some mice are gasping at P0

nervous system

increased neuron apoptosis ( J:201099 )

• slightly in the cortex and striatum at E14.5

• in the cortex and striatum at E16.5

• at E18.5

abnormal neuronal precursor proliferation ( J:201099 )

• increased at E14.5

• modest in the ventricular zone and more so away from the ventricular zone

decreased midbrain size ( J:201099 )

• at E18.5

enlarged brain ventricles ( J:201099 )

• at E18.5

abnormal choroid plexus morphology ( J:201099 )

• reduced at E18.5

absent anterior commissure ( J:201099 )

abnormal brain internal capsule morphology ( J:201099 )

• reduced striatal axons leading to and forming the internal capsule

abnormal basal ganglion morphology ( J:201099 )

• reduced at E11.5 (slightly), E14.5 (increasing severity in the caudal portion), E16.5 (more severe in the posterior region) and E18.5

abnormal telencephalon morphology ( J:201099 )

• reduced neuroepithelium thickness in the caudolateral telencephalon at E18.5

abnormal cortical plate morphology ( J:201099 )

• wave-like perturbation in the cerebral cortex at E18.5

absent corpus callosum ( J:201099 )

abnormal cerebral cortex morphology ( J:201099 )

• hypoplastic, irregular ventricular zone at E18.5

thin cerebral cortex ( J:201099 )

• at E16.5 (more severe in the posterior region) and E18.5

small olfactory bulb ( J:201099 )

• at E18.5

small cerebellum ( J:201099 )

• at E18.5

craniofacial

short snout ( J:201099 )

• slightly at E18.5

cellular

increased neuron apoptosis ( J:201099 )

• slightly in the cortex and striatum at E14.5

• in the cortex and striatum at E16.5

• at E18.5

abnormal neuronal precursor proliferation ( J:201099 )

• increased at E14.5

• modest in the ventricular zone and more so away from the ventricular zone

growth/size/body

short snout ( J:201099 )

• slightly at E18.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
complex cortical dysplasia with other brain malformations 7		DOID:0090132	OMIM:610031	J:201099

Allelic Composition	Tubb2b^brdp/Tubb2b^brdp
Genetic Background	involves: A/J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubb2b^brdp mutation (0 available); any Tubb2b mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

hydrocephaly ( J:174027 )

• mild

abnormal telencephalon morphology ( J:174027 )

• telencephalic dysmorphology

• significant thinning of the caudo-lateral telencephalic tissue

small olfactory bulb ( J:174027 )

Allelic Composition	Tubb2b^brdp/Tubb2b⁺
Genetic Background	involves: A/J * CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubb2b^brdp mutation (0 available); any Tubb2b mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:201099 )

N	• Background Sensitivity: mice on an outbred background exhibit improved fertility compared with mice on an inbred background

Allelic Composition	Tubb2b^brdp/Tubb2b⁺
Genetic Background	involves: A/J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubb2b^brdp mutation (0 available); any Tubb2b mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:201099 )

N	• mice exhibit normal length and density of spermatid tails in the developing testes

reduced fertility ( J:201099 )

• extremely low

• Background Sensitivity: mice on an inbred background exhibit reduced fertility compared with mice on an outbred background

nervous system

abnormal brain interneuron morphology ( J:201099 )

• decreased as determined by marker expression

abnormal cerebral cortex morphology ( J:201099 )

behavior/neurological

hyperactivity ( J:201099 )

Allelic Composition	Tubb2b^brdp/Tubb2b⁺
Genetic Background	involves: A/J * FVB/N * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubb2b^brdp mutation (0 available); any Tubb2b mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:201099 )

N	• Background Sensitivity: mice on an outbred background exhibit improved fertility compared with mice on an inbred background

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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