All Phenotypes Tubb2b<brdp> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tubb2b^brdp/Tubb2b^brdp	involves: A/J * FVB	MGI:5522833
hm2	Tubb2b^brdp/Tubb2b^brdp	involves: A/J * FVB/N	MGI:5056381
ht3	Tubb2b^brdp/Tubb2b⁺	involves: A/J * CD-1 * FVB/N	MGI:5522835
ht4	Tubb2b^brdp/Tubb2b⁺	involves: A/J * FVB	MGI:5522834
ht5	Tubb2b^brdp/Tubb2b⁺	involves: A/J * FVB/N * ICR	MGI:5522836

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:201099 )

• mice do not survive birth

respiratory system

respiratory distress ( J:201099 )

• some mice are gasping at P0

nervous system

increased neuron apoptosis ( J:201099 )

• slightly in the cortex and striatum at E14.5

• in the cortex and striatum at E16.5

• at E18.5

abnormal neuronal precursor proliferation ( J:201099 )

• increased at E14.5

• modest in the ventricular zone and more so away from the ventricular zone

decreased midbrain size ( J:201099 )

• at E18.5

enlarged brain ventricles ( J:201099 )

• at E18.5

abnormal choroid plexus morphology ( J:201099 )

• reduced at E18.5

absent anterior commissure ( J:201099 )

abnormal brain internal capsule morphology ( J:201099 )

• reduced striatal axons leading to and forming the internal capsule

abnormal basal ganglion morphology ( J:201099 )

• reduced at E11.5 (slightly), E14.5 (increasing severity in the caudal portion), E16.5 (more severe in the posterior region) and E18.5

abnormal telencephalon morphology ( J:201099 )

• reduced neuroepithelium thickness in the caudolateral telencephalon at E18.5

abnormal cortical plate morphology ( J:201099 )

• wave-like perturbation in the cerebral cortex at E18.5

absent corpus callosum ( J:201099 )

abnormal cerebral cortex morphology ( J:201099 )

• hypoplastic, irregular ventricular zone at E18.5

thin cerebral cortex ( J:201099 )

• at E16.5 (more severe in the posterior region) and E18.5

small olfactory bulb ( J:201099 )

• at E18.5

small cerebellum ( J:201099 )

• at E18.5

craniofacial

short snout ( J:201099 )

• slightly at E18.5

cellular

increased neuron apoptosis ( J:201099 )

• slightly in the cortex and striatum at E14.5

• in the cortex and striatum at E16.5

• at E18.5

abnormal neuronal precursor proliferation ( J:201099 )

• increased at E14.5

• modest in the ventricular zone and more so away from the ventricular zone

growth/size/body

short snout ( J:201099 )

• slightly at E18.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
complex cortical dysplasia with other brain malformations 7		DOID:0090132	OMIM:610031	J:201099

Allelic Composition	Tubb2b^brdp/Tubb2b^brdp
Genetic Background	involves: A/J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubb2b^brdp mutation (0 available); any Tubb2b mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

hydrocephaly ( J:174027 )

• mild

abnormal telencephalon morphology ( J:174027 )

• telencephalic dysmorphology

• significant thinning of the caudo-lateral telencephalic tissue

small olfactory bulb ( J:174027 )

Allelic Composition	Tubb2b^brdp/Tubb2b⁺
Genetic Background	involves: A/J * CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubb2b^brdp mutation (0 available); any Tubb2b mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:201099 )

N	• Background Sensitivity: mice on an outbred background exhibit improved fertility compared with mice on an inbred background

Allelic Composition	Tubb2b^brdp/Tubb2b⁺
Genetic Background	involves: A/J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubb2b^brdp mutation (0 available); any Tubb2b mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:201099 )

N	• mice exhibit normal length and density of spermatid tails in the developing testes

reduced fertility ( J:201099 )

• extremely low

• Background Sensitivity: mice on an inbred background exhibit reduced fertility compared with mice on an outbred background

nervous system

abnormal brain interneuron morphology ( J:201099 )

• decreased as determined by marker expression

abnormal cerebral cortex morphology ( J:201099 )

behavior/neurological

hyperactivity ( J:201099 )

Allelic Composition	Tubb2b^brdp/Tubb2b⁺
Genetic Background	involves: A/J * FVB/N * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubb2b^brdp mutation (0 available); any Tubb2b mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:201099 )

N	• Background Sensitivity: mice on an outbred background exhibit improved fertility compared with mice on an inbred background

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24