All Phenotypes Pgap2<clpex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pgap2^clpex
cleft lip and palate, exencephaly
MGI:5056366

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pgap2^clpex/Pgap2^clpex	involves: A/J * FVB/N	MGI:5056383
ht2	Pgap2^clpex/Pgap2^{tm1a(EUCOMM)Wtsi}	involves: A/J * C57BL/6N	MGI:6342273
cn3	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Pgap2^clpex/Pgap2^clpex	involves: 129S4/SvJaeSor * A/J * C57BL/6J * CBA/J	MGI:6342276

Allelic Composition	Pgap2^clpex/Pgap2^clpex
Genetic Background	involves: A/J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgap2^clpex mutation (0 available); any Pgap2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

exencephaly ( J:174027 )

craniofacial

cleft upper lip ( J:174027 )

cleft palate ( J:174027 )

flat head ( J:174027 )

• flattened head

digestive/alimentary system

cleft palate ( J:174027 )

growth/size/body

cleft upper lip ( J:174027 )

cleft palate ( J:174027 )

flat head ( J:174027 )

• flattened head

Allelic Composition	Pgap2^clpex/Pgap2^{tm1a(EUCOMM)Wtsi}
Genetic Background	involves: A/J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgap2^clpex mutation (0 available); any Pgap2 mutation (23 available)
Pgap2^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Pgap2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

myocardium hypoplasia ( J:277316 )

• reduced thickness of myocardium at age E13.5

thin interventricular septum ( J:277316 )

• underdeveloped at age E13.5

heart valve hypoplasia ( J:277316 )

• underdeveloped at age E13.5

pericardial effusion ( J:277316 )

• at age E13.5

craniofacial

bilateral cleft upper lip ( J:277316 )

• bilateral cleft lip at age E13.5

embryo

abnormal neural tube morphology ( J:277316 )

• at age E13.5

growth/size/body

bilateral cleft upper lip ( J:277316 )

• bilateral cleft lip at age E13.5

homeostasis/metabolism

pericardial effusion ( J:277316 )

• at age E13.5

edema ( J:277316 )

• at age E13.5

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:277316 )

• by age E13.5-14.5

muscle

myocardium hypoplasia ( J:277316 )

• reduced thickness of myocardium at age E13.5

nervous system

abnormal neural tube morphology ( J:277316 )

• at age E13.5

vision/eye

microphthalmia ( J:277316 )

• at age E13.5

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Pgap2^clpex/Pgap2^clpex
Genetic Background	involves: 129S4/SvJaeSor * A/J * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Pgap2^clpex mutation (0 available); any Pgap2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal lateral nasal prominence morphology ( J:277316 )

abnormal medial nasal prominence morphology ( J:277316 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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