Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm2(OVA/EGFP)Dwir}
• Allele Name: targeted mutation 2, Dagmar Wirth
• Allele ID: MGI:5056498
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm2(OVA/EGFP)Dwir/Gt(ROSA)26Sor^+ Alb^tm1(cre/ERT2)Mtz/Alb^+	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:5056503
cn2	Gt(ROSA)26Sor^tm2(OVA/EGFP)Dwir/Gt(ROSA)26Sor^+ Tg(TcraTcrb)1100Mjb/0 Alb^tm1(cre/ERT2)Mtz/Alb^+	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:5056505

Genotype
MGI:5056503

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm2(OVA/EGFP)Dwir}/Gt(ROSA)26Sor⁺; Alb^{tm1(cre/ERT2)Mtz}/Alb⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

abnormal hepatocyte physiology ( J:173806 )

• hepatocytes from tamoxifen-treated mice are capable of activating OT-I CD8+ T cells unlike cells from un-induced mice

Genotype
MGI:5056505

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm2(OVA/EGFP)Dwir}/Gt(ROSA)26Sor⁺; Tg(TcraTcrb)1100Mjb/0; Alb^{tm1(cre/ERT2)Mtz}/Alb⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

homeostasis/metabolism

increased circulating alanine transaminase level ( J:173806 )

• tamoxifen-treated mice exhibit increased serum alanine transaminase levels compared with un-induced mice

• however, un-induced mice exhibit normal alanine transaminase levels