Analysis Tools
mortality/aging
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• homozygous mice were born at a lower rate than predicted by the Mendelian ratio
• however, viable homozygous mice survived to adulthood and demonstrated no detectable physical abnormality
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immune system
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• endogenous histone H3 citrullination was note detected in neutrophils from homozygous mutant mice neutrophils
• NET formation or H3 cirtullination was not induced after LPS treatment or the pathogenic bacteria strain S. flexneri infection of homozygous mutant mice neutrophils
• number and morphology of neutrophil are not affected
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• mutant neutrophils have a decreased ability in killing bacteria in vitro
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• mutant mice are more susceptible to infection by M1 GAS or M1-delta-Sda1 GAS bacteria
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hematopoietic system
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• endogenous histone H3 citrullination was note detected in neutrophils from homozygous mutant mice neutrophils
• NET formation or H3 cirtullination was not induced after LPS treatment or the pathogenic bacteria strain S. flexneri infection of homozygous mutant mice neutrophils
• number and morphology of neutrophil are not affected
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• mutant neutrophils have a decreased ability in killing bacteria in vitro
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cellular
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• mutant neutrophils have a decreased ability in killing bacteria in vitro
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