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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Efnb2tm3.1Henk
targeted mutation 3.1, Mark Henkemeyer
MGI:5085271
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Efnb2tm3.1Henk/Efnb2tm3.1Henk involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:5085272
ht2
 		Efnb2tm3.1Henk/Efnb2+ involves: 129S1/Sv * 129X1/SvJ MGI:5306608
ht3
 		Efnb2tm1Henk/Efnb2tm3.1Henk involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:5085273


Genotype
MGI:5085272
hm1
Allelic
Composition		 Efnb2tm3.1Henk/Efnb2tm3.1Henk
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb2tm3.1Henk mutation (0 available); any Efnb2 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:173636 )
• many die before adulthood but some can be recovered as adults

digestive/alimentary system
digestive/alimentary phenotype ( J:173636 )
N
• no defects in urorectal, tracheoesophageal or palatal development are seen




Genotype
MGI:5306608
ht2
Allelic
Composition		 Efnb2tm3.1Henk/Efnb2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb2tm3.1Henk mutation (0 available); any Efnb2 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• some mice exhibit dorsal and ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:5085273
ht3
Allelic
Composition		 Efnb2tm1Henk/Efnb2tm3.1Henk
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb2tm1Henk mutation (0 available); any Efnb2 mutation (29 available)
Efnb2tm3.1Henk mutation (0 available); any Efnb2 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
hypospadia ( J:173636 )
• seen in 86% of mice

nervous system
abnormal axon morphology ( J:176056 )
• some mice exhibit dorsal and ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory