Phenotypes associated with this allele

• Allele Symbol: Cyfip2^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:5085782
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyfip2^tm1(KOMP)Vlcg/Cyfip2^tm1(KOMP)Vlcg	involves: C57BL/6J * C57BL/6NTac	MGI:5774701
ht2	Cyfip2^tm1(KOMP)Vlcg/Cyfip2^+	involves: C57BL/6J * C57BL/6NTac	MGI:5774702
cx3	Cyfip2^tm1(KOMP)Vlcg/Cyfip2^+ Fmr1^tm1Cgr/Y	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac	MGI:5774703

Genotype
MGI:5774701

hm1

• Allelic Composition: Cyfip2^{tm1(KOMP)Vlcg}/Cyfip2^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:219363 )

• mice are lethal before weaning age

Genotype
MGI:5774702

ht2

• Allelic Composition: Cyfip2^{tm1(KOMP)Vlcg}/Cyfip2⁺
• Genetic Background: involves: C57BL/6J * C57BL/6NTac

behavior/neurological

abnormal anxiety-related response ( J:219363 )

♂ • increased transition between light and dark areas in a light-dark box assay

decreased startle reflex ( J:219363 )

♂

hyperactivity ( J:219363 )

♂

nervous system

nervous system phenotype ( J:219363 )

♂N • mice exhibit normal hippocampal synaptic plasticity

abnormal dendritic spine morphology ( J:219363 )

♂ • increased number of mature spines and total protrusions in cortical neurons

♂ • DHPG-treated cortical neurons fail to exhibit a decrease in the number of mature spines and an increased average length of dendritic protrusions unlike in wild-type cortical neurons

increased prepulse inhibition ( J:219363 )

♂

Genotype
MGI:5774703

cx3

• Allelic Composition: Cyfip2^{tm1(KOMP)Vlcg}/Cyfip2⁺; Fmr1^tm1Cgr/Y
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

behavior/neurological

abnormal anxiety-related response ( J:219363 )

♂ • increased transition between light and dark areas in a light-dark box assay that is more so than in single mutants with more time spent in the light area

decreased startle reflex ( J:219363 )

♂

hyperactivity ( J:219363 )

♂ • aggravated compared with Fmr1^tm1Cgr males

increased stereotypic behavior ( J:219363 )

♂

nervous system

abnormal dendritic spine morphology ( J:219363 )

♂ • hippocampal neurons exhibit increased density of think (immature) spines compared with wild-type neurons to the same extent as in Fmr1^tm1Cgr males

♂ • cortical neurons exhibit increased density of think (immature) spines compared with wild-type neurons to the same a greater extent than in Fmr1^tm1Cgr males

increased prepulse inhibition ( J:219363 )

♂