Analysis Tools
endocrine/exocrine glands
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• red oil O staining shows decreased staining on the surface of the skin but increased accumulation of lipids in the hair follicle pilary canal indicative of impaired lipid secretion from the sebaceous gland to the skin surface
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growth/size/body
weight loss
(
J:252017
)
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• although normal weight when younger, at 13 and 18 months of age homozygotes have decreased body weight relative to wild-type or heterozygous controls
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homeostasis/metabolism
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• skin of homozygotes has very low alkaline ceramidase activity on very-long-acyl-chain ceramide C24:1 ceramide, but only a moderate reduction in alkaline ceramidase activity on long chain ceramide C18:1 ceramide
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mortality/aging
| N |
• intercrosses of heterozygotes yields normal Mendelian ratio of homozygotes, heterozygotes and wild-type offspring
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integument
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• red oil O staining shows decreased staining on the surface of the skin but increased accumulation of lipids in the hair follicle pilary canal indicative of impaired lipid secretion from the sebaceous gland to the skin surface
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• accumulation of lipids in the opening of the pilary canal may be responsible for the dilation of the infundibulum
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• the pilary canal in the hair follicle infundibulum region is wider and morphologically irregular
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• the first telogen to anagen transition is delayed and then both telogen and anagen cycles are shorter than normal
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• hair follicle stem cells have decreased maintenance of quiescence, thus there are fewer than normal hair follicle stem cells in adults and this deficiency worsens with age
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• increased cell proliferation and apoptosis with decreased cell differentiation in the epidermis
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• increased cell proliferation and apoptosis with decreased cell differentiation in the epidermis
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