All Phenotypes Nlrp10<tm1Seis> MGI Mouse

decreased dendritic cell number ( J:183989 )

• the CD11b1+ CD2072- CD1032- DC subset is nearly absent in the lymph nodes of immunized mice

• global defect in adaptive immune responses

• when mice are immunized with hapten trinitrophenyl linked to keyhole limpet haemocyanin

• however, no decrease is seen in the T cell independent IgG3 levels

abnormal T-helper 2 physiology ( J:183989 )

• ovalbumin and aluminum hydroxide or complete Freund's adjuvant with myelin oligodendrocyte glycoprotein peptide induced responses in the lung, lymph nodes and systemic antibody production are significantly reduced

abnormal dendritic cell physiology ( J:183989 )

• 18 h after stimulation by fluorescein isothiocyanate skin painting dendritic cells fail to reach the lymph nodes

• this defect can be partially overcome by use of high antigen doses

• splenic DCs fail to relocalize to the T cell zone following LPS stimulation

• however in vitro, bone marrow derived dendritic cells respond normally to a gradient of CCL19 and CCL21, CXCL12, and S1P and no defect is seen in the ability of DCs to transverse an endothelial layer suggesting there is a defect in DC emigration from inflamed tissues

• when injected into wild-type hosts mutant DCs remain near the injection site unlike wild-type cells

• bone marrow derived dendritic cells loaded with antigen are unable to activate T cells

decreased interferon-gamma secretion ( J:183989 )

• in lymph node cells from mice sensitized intraperitoneally with OVA/alum and challenged intranasally with OVA

decreased interleukin-17 secretion ( J:183989 )

• in lymph node cells from mice sensitized intraperitoneally with OVA/alum and challenged intranasally with OVA

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:183989 )

• fail to develop signs of EAE

decreased susceptibility to endotoxin shock ( J:183989 )

• defect in lipopolysaccharide induced airway inflammation model