Phenotypes associated with this allele

• Allele Symbol: Sec23ip^tm1.1Katn
• Allele Name: targeted mutation 1.1, Katsuko Tani
• Allele ID: MGI:5085903
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sec23ip^tm1.1Katn/Sec23ip^tm1.1Katn	involves: C57BL/6 * CBA	MGI:5085904

Genotype
MGI:5085904

hm1

• Allelic Composition: Sec23ip^tm1.1Katn/Sec23ip^tm1.1Katn
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm mitochondrial sheath morphology ( J:174226 )

♂

abnormal sperm nucleus morphology ( J:174226 )

♂ • sperm exhibit a round-shaped nucleus

abnormal spermatid morphology ( J:174226 )

♂ • only a few elongated spermatids are observed

abnormal spermiogenesis ( J:174226 )

♂ • spermatids near the lumen of the seminiferous tubules are not elongated

abnormal acrosome assembly ( J:174226 )

♂ • only a few PNA-, sp56-positive acrosome structures are observed

globozoospermia ( J:174226 )

♂ • many sperm in the cauda epididymis have round heads

reduced male fertility ( J:174226 )

♂ • failure of conception is frequently observed

♂ • however, female fertility is normal

decreased fertilization frequency ( J:174226 )

♂ • IVF assays using zona pellucida-intact eggs showed that sperm have a markedly reduced fertilization rate (31%) relative to control mice (84%)

cellular

abnormal sperm mitochondrial sheath morphology ( J:174226 )

♂

abnormal acrosome assembly ( J:174226 )

♂ • only a few PNA-, sp56-positive acrosome structures are observed

globozoospermia ( J:174226 )

♂ • many sperm in the cauda epididymis have round heads

abnormal sperm nucleus morphology ( J:174226 )

♂ • sperm exhibit a round-shaped nucleus

abnormal spermatid morphology ( J:174226 )

♂ • only a few elongated spermatids are observed