Phenotypes associated with this allele

• Allele Symbol: Cd1d1^tm1.2Aben
• Allele Name: targeted mutation 1.2, Albert Bendelac
• Allele ID: MGI:5085993
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd1d1^tm1.2Aben/Cd1d1^tm1.2Aben	B6(C)-Cd1d1^tm1.2Aben/J	MGI:5085995

Genotype
MGI:5085995

hm1

• Allelic Composition: Cd1d1^tm1.2Aben/Cd1d1^tm1.2Aben
• Genetic Background: B6(C)-Cd1d1^tm1.2Aben/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:177038 )

• following mouse focal cerebral ischemia

• propranolol does not improve survival

• however, administration of an antibiotic improves survival

immune system

abnormal CD4-positive T cell differentiation ( J:177038 )

• following mouse focal cerebral ischemia, mice exhibit a switch in immune programming from Th1 to Th2 cytokines unlike in wild-type mice

abnormal T cell activation ( J:177038 )

• following mouse focal cerebral ischemia

lung inflammation ( J:177038 )

• following mouse focal cerebral ischemia, mice develop greater pulmonary damage and more prominent pulmonary neutrophil infiltration suggestive of earlier pneumonia-like symptoms compared with wild-type mice

increased susceptibility to bacterial infection ( J:177038 )

• following mouse focal cerebral ischemia

increased susceptibility to bacterial infection induced morbidity/mortality ( J:177038 )

• following mouse focal cerebral ischemia

• propranolol does not improve survival

• however, administration of an antibiotic improves survival

respiratory system

lung inflammation ( J:177038 )

• following mouse focal cerebral ischemia, mice develop greater pulmonary damage and more prominent pulmonary neutrophil infiltration suggestive of earlier pneumonia-like symptoms compared with wild-type mice

nervous system

increased susceptibility to ischemic brain injury ( J:177038 )

• following mouse focal cerebral ischemia, mice exhibit increased bacterial counts in the blood and lungs, greater pulmonary damage and more prominent pulmonary neutrophil infiltration suggestive of earlier pneumonia-like symptoms, decreased T cell activation, a switch in immune programming from Th1 to Th2 cytokines, and increased mortality compared with wild-type mice

• propranolol does not improve survival

• however, infarct size is normal and administration of an antibiotic improves survival

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:177038 )

• following mouse focal cerebral ischemia, mice exhibit increased bacterial counts in the blood and lungs, greater pulmonary damage and more prominent pulmonary neutrophil infiltration suggestive of earlier pneumonia-like symptoms, decreased T cell activation, a switch in immune programming from Th1 to Th2 cytokines, and increased mortality compared with wild-type mice

• propranolol does not improve survival

• however, infarct size is normal and administration of an antibiotic improves survival

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:177038 )

• following mouse focal cerebral ischemia, mice exhibit a switch in immune programming from Th1 to Th2 cytokines unlike in wild-type mice

abnormal T cell activation ( J:177038 )

• following mouse focal cerebral ischemia