Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^tm2Bet
• Allele Name: targeted mutation 2, Bernhard Bettler
• Allele ID: MGI:5085997
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gt(ROSA)26Sor^tm2Bet/Gt(ROSA)26Sor^tm2Bet	involves: BALB/c	MGI:5086105
cn2	Gt(ROSA)26Sor^tm2Bet/Gt(ROSA)26Sor^tm2Bet Speer6-ps1^Tg(Alb-cre)21Mgn/?	involves: BALB/c * C57BL/6 * DBA	MGI:5086106

Genotype
MGI:5086105

hm1

• Allelic Composition: Gt(ROSA)26Sor^tm2Bet/Gt(ROSA)26Sor^tm2Bet
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:174261 )

• born in expected numbers

• display no overt phenotype

Genotype
MGI:5086106

cn2

• Allelic Composition: Gt(ROSA)26Sor^tm2Bet/Gt(ROSA)26Sor^tm2Bet; Speer6-ps1^{Tg(Alb-cre)21Mgn}/?
• Genetic Background: involves: BALB/c * C57BL/6 * DBA

liver/biliary system

increased hepatocyte proliferation ( J:174261 )

• hepatocyte numbers are extremely low at 4 days of age however

abnormal bile duct morphology ( J:174261 )

abnormal bile duct development ( J:174261 )

• ductal plate cells persist to 90 days unlike controls where they are lost by 2 weeks of age

abnormal liver morphology ( J:174261 )

abnormal intrahepatic bile duct morphology ( J:174261 )

• biliary epithelial cells form ectopic tubular structures in lobules at 4 days of age

• some ectopic structures have lumina while others are disorganized

• most ectopic structures are lost by 10 days of age

• increased number of bile ducts relative to controls at 90 days of age

increased liver weight ( J:174261 )

decreased hepatocyte number ( J:174261 )

• numbers are extremely low at 4 days of age

endocrine/exocrine glands

abnormal bile duct morphology ( J:174261 )

abnormal bile duct development ( J:174261 )

• ductal plate cells persist to 90 days unlike controls where they are lost by 2 weeks of age

abnormal intrahepatic bile duct morphology ( J:174261 )

• biliary epithelial cells form ectopic tubular structures in lobules at 4 days of age

• some ectopic structures have lumina while others are disorganized

• most ectopic structures are lost by 10 days of age

• increased number of bile ducts relative to controls at 90 days of age

cellular

increased hepatocyte proliferation ( J:174261 )

• hepatocyte numbers are extremely low at 4 days of age however

growth/size/body

increased liver weight ( J:174261 )