Phenotypes associated with this allele

• Allele Symbol: Tg(Eno2-Glrb)456Wha
• Allele Name: transgene insertion 456, Hans Weiher
• Allele ID: MGI:5086014
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Glrb^spa/Glrb^spa Tg(Eno2-Glrb)456Wha/Tg(Eno2-Glrb)456Wha	involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2	MGI:5086227
cx2	Glrb^spa/Glrb^spa Tg(Eno2-Glrb)456Wha/0	involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2	MGI:5086228

Genotype
MGI:5086227

cx1

• Allelic Composition: Glrb^spa/Glrb^spa; Tg(Eno2-Glrb)456Wha/Tg(Eno2-Glrb)456Wha
• Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:60037 )

N • male mice exhibit normal fertility unlike Glrb^spa homozygotes

behavior/neurological

impaired righting response ( J:60037 )

• in 14% of mice compared with 100% of Glrb^spa homozygotes

limb grasping ( J:60037 )

• in 32% of mice compared with 100% of Glrb^spa homozygotes

tremors ( J:60037 )

• between 2 and 10 days, mice exhibit transient handling-induced tremors

• after 20 to 35 days, mice exhibit tremors that are less strong than in Glrb^spa homozygotes

Genotype
MGI:5086228

cx2

• Allelic Composition: Glrb^spa/Glrb^spa; Tg(Eno2-Glrb)456Wha/0
• Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

reproductive system

reduced male fertility ( J:60037 )

♂ • not as severe as in Glrb^spa homozygotes

behavior/neurological

impaired righting response ( J:60037 )

• in 52% of mice compared with 100% of Glrb^spa homozygotes

hyperekplexia ( J:60037 )

limb grasping ( J:60037 )

• in 71% of mice compared with 100% of Glrb^spa homozygotes

tremors ( J:60037 )

• at 14 to 17 days old

muscle

muscle hypertonia ( J:60037 )

• mice exhibit a less severe spastic phenotype compared with Glrb^spa homozygotes