Phenotypes associated with this allele

• Allele Symbol: Homer1^tm2Mhd
• Allele Name: targeted mutation 2, Marlin H Dehoff
• Allele ID: MGI:5086112
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Homer1^tm2Mhd/Homer1^tm2Mhd	involves: 129S1/Sv * 129X1/SvJ	MGI:5461827
hm2	Homer1^tm2Mhd/Homer1^tm2Mhd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5086117

Genotype
MGI:5461827

hm1

• Allelic Composition: Homer1^tm2Mhd/Homer1^tm2Mhd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal nociception after inflammation ( J:191366 )

♂ • formalin-treated mice exhibit a decreased response to pain during the second phase, but not the first phase, compared with wild-type mice

Genotype
MGI:5086117

hm2

• Allelic Composition: Homer1^tm2Mhd/Homer1^tm2Mhd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

nervous system

abnormal miniature excitatory postsynaptic currents ( J:174500 )

• pyramidal neurons exhibit an increased in the average amplitude of miniature excitatory postsynaptic currents (EPSCs) compared with wild-type neurons

• treatment with TTX or bicuculline does not alter mEPSC amplitudes unlike in similarly treated wild-type mice

• following maximal electroconvulsive seizure, mice fail to exhibit a decrease in mEPSC amplitudes unlike wild-type mice

• application of Bay and MPEP does not increase mEPSC amplitude unlike in wild-type mice

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:174500 )

• treatment with TTX or bicuculline does not alter mEPSC amplitudes unlike in similarly treated wild-type mice

• application of Bay and MPEP does not increase mEPSC amplitude unlike in wild-type mice