Analysis Tools
behavior/neurological
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• mice treated with tamoxifen at 4 weeks of age show a reduced tendency to freeze when transferred to a novel environment
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cardiovascular system
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• most discs are severely changed with disconnection between myofilaments and the presence of big vacuoles-containing parts of membranes in tamoxifen treated mice
• the outline of the junction is also changed with the distance between zonula adherens being wider and containing clot like contents in some areas
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• complete atrioventricular block with temporal dissociation between atrial depolarization and ventricular depolarization in mice treated with tamoxifen at 4 weeks of age at 24 weeks after the last tamoxifen treatment
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digestive/alimentary system
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• atrophy and metaplastic phenotype are present as early as 3 weeks after tamoxifen treatment and is maintained up to 18 months after tamoxifen treatment
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• almost a complete lack of acinar cells in mice treated with tamoxifen at 4 weeks of age
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• in mice treated with tamoxifen at 4 weeks of age
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• dilated intestine in mice treated with tamoxifen at 4 weeks of age at up to 18 months after the last tamoxifen treatment
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endocrine/exocrine glands
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• in tamoxifen treated mice 2 -3 days after the last treatment
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• in tamoxifen treated mice 2 -3 days after the last treatment
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• in mice treated with tamoxifen at 4 weeks of age the pancreas consists of mainly adipose tissue in which apparently normal islets of Langerhans are interspersed
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• atrophy and metaplastic phenotype are present as early as 3 weeks after tamoxifen treatment and is maintained up to 18 months after tamoxifen treatment
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• almost a complete lack of acinar cells in mice treated with tamoxifen at 4 weeks of age
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• in mice treated with tamoxifen at 4 weeks of age
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• dramatically smaller in mice treated with tamoxifen at 4 weeks of age at up to 18 months after the last tamoxifen treatment
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• duct-like tubular complexes replace the acinar cells in mice treated with tamoxifen at 4 weeks of age
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hematopoietic system
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• in tamoxifen treated mice 2 -3 days after the last treatment
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• in tamoxifen treated mice 2 -3 days after the last treatment
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immune system
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• in tamoxifen treated mice 2 -3 days after the last treatment
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• in tamoxifen treated mice 2 -3 days after the last treatment
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muscle
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• most discs are severely changed with disconnection between myofilaments and the presence of big vacuoles-containing parts of membranes in tamoxifen treated mice
• the outline of the junction is also changed with the distance between zonula adherens being wider and containing clot like contents in some areas
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