Phenotypes associated with this allele

• Allele Symbol: Pcp4^tm1.1Jim
• Allele Name: targeted mutation 1.1, James I Morgan
• Allele ID: MGI:5086270
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pcp4^tm1.1Jim/Pcp4^tm1.1Jim	involves: 129S1/Sv * C57BL/6 * CBA	MGI:5086277

Genotype
MGI:5086277

hm1

• Allelic Composition: Pcp4^tm1.1Jim/Pcp4^tm1.1Jim
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:174091 )

N • the cerebella exhibit normal Purkinje cell morphology and density

abnormal synaptic plasticity ( J:174091 )

• the protocol that induces long term depression in the parallel fiber-Purkinje cell synapses of wild-type mice produces long term potentiation

• however, paired-pulse ratio is normal

behavior/neurological

behavior/neurological phenotype ( J:174091 )

N • mice exhibit normal performance in running wheel, treadmill, and hanging wire tests

abnormal motor learning ( J:174091 )

• mice exhibit impaired motor learning on a rotarod compared with wild-type mice