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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Serpinb9tm1.1Pib
targeted mutation 1.1, Phillip I Bird
MGI:5140012
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Serpinb9tm1.1Pib/Serpinb9tm1.1Pib involves: BALB/cJ * C57BL/6J MGI:6107546
cx2
 		Gzmbtm1Ley/Gzmbtm1Ley
Serpinb9tm1.1Pib/Serpinb9tm1.1Pib 		involves: 129S2/SvPas * BALB/cJ * C57BL/6J MGI:6107547


Genotype
MGI:6107546
hm1
Allelic
Composition		 Serpinb9tm1.1Pib/Serpinb9tm1.1Pib
Genetic
Background		 involves: BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpinb9tm1.1Pib mutation (0 available); any Serpinb9 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:252016 )
N
• mice exhibit normal thymus and spleen cellularity and numbers of dendritic cells, splenic CD4 T cells, CD8 T cells, NK cells and CD103+CD8+ dendritic cells
abnormal immune system morphology ( J:252016 )
• authors state that the base phenotype resembles that of Serpinb9tm1Arp
abnormal immune system physiology ( J:252016 )
• authors state that the base phenotype resembles that of Serpinb9tm1Arp
decreased cytotoxic T cell apoptosis ( J:252016 )
• in mice immunized with apoptotic cells displaying ovalbumin due to a dendritic cell dependent priming deficit
abnormal dendritic cell antigen presentation ( J:252016 )
• impaired cross-presentation
• however, dendritic cells exhibit normal antigen uptake, survival after antigenic challenge and antigen degradation machinery

cellular
decreased cytotoxic T cell apoptosis ( J:252016 )
• in mice immunized with apoptotic cells displaying ovalbumin due to a dendritic cell dependent priming deficit

hematopoietic system
decreased cytotoxic T cell apoptosis ( J:252016 )
• in mice immunized with apoptotic cells displaying ovalbumin due to a dendritic cell dependent priming deficit




Genotype
MGI:6107547
cx2
Allelic
Composition		 Gzmbtm1Ley/Gzmbtm1Ley
Serpinb9tm1.1Pib/Serpinb9tm1.1Pib
Genetic
Background		 involves: 129S2/SvPas * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gzmbtm1Ley mutation (7 available); any Gzmb mutation (29 available)
Serpinb9tm1.1Pib mutation (0 available); any Serpinb9 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased cytotoxic T cell apoptosis ( J:252016 )
• as in Serpinb9tm1.1Pib homozygotes in mice immunized with apoptotic cells displaying ovalbumin

cellular
decreased cytotoxic T cell apoptosis ( J:252016 )
• as in Serpinb9tm1.1Pib homozygotes in mice immunized with apoptotic cells displaying ovalbumin

hematopoietic system
decreased cytotoxic T cell apoptosis ( J:252016 )
• as in Serpinb9tm1.1Pib homozygotes in mice immunized with apoptotic cells displaying ovalbumin




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory