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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cygbtm1Nka
targeted mutation 1, Norifumi Kawada
MGI:5140136
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cygbtm1Nka/Cygbtm1Nka B6.Cg-Cygbtm1Nka MGI:5140137
ht2
 		Cygbtm1Nka/Cygb+ B6.Cg-Cygbtm1Nka MGI:5140138


Genotype
MGI:5140137
hm1
Allelic
Composition		 Cygbtm1Nka/Cygbtm1Nka
Genetic
Background		 B6.Cg-Cygbtm1Nka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cygbtm1Nka mutation (0 available); any Cygb mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:174134 )
• treatment with 25 ppm DEN in the drinking water induced lung and liver tumors in all mice by 25 weeks post treatment, compared to only about 44% of similarly treated wild-type mice
• treatment with a lower dose of DEN (0.05 ppm), which does not induce tumors in wild-type mice, induces liver or lung tumors in over 40% of mice
abnormal tumor pathology ( J:174134 )
• increase in the number of proliferating cells in DEN induced liver tumors
increased tumor growth/size ( J:174134 )
• DEN treated mice develop larger tumors compared to similarly treated wild-type controls

homeostasis/metabolism
increased physiological sensitivity to xenobiotic ( J:174134 )
• increase in the severity of N,N-diethylnitrosamine (DEN, 25 ppm) induced liver fibrosis
increased incidence of tumors by chemical induction ( J:174134 )
• treatment with 25 ppm DEN in the drinking water induced lung and liver tumors in all mice by 25 weeks post treatment, compared to only about 44% of similarly treated wild-type mice
• treatment with a lower dose of DEN (0.05 ppm), which does not induce tumors in wild-type mice, induces liver or lung tumors in over 40% of mice

liver/biliary system
abnormal liver physiology ( J:174134 )
• accumulation of nitrotyrosine in livers from DEN treated mice




Genotype
MGI:5140138
ht2
Allelic
Composition		 Cygbtm1Nka/Cygb+
Genetic
Background		 B6.Cg-Cygbtm1Nka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cygbtm1Nka mutation (0 available); any Cygb mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:174134 )
• treatment with 25 ppm N,N-diethylnitrosamine (DEN) in the drinking water induced lung and liver tumors in all mice by 25 weeks post treatment, compared to only about 44% of similarly treated wild-type mice
• treatment with a lower dose of DEN (0.05 ppm), which does not induce tumors in wild-type mice, induces liver or lung tumors in some mice
increased tumor growth/size ( J:174134 )
• DEN treated mice develop larger tumors compared to similarly treated wild-type controls

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:174134 )
• treatment with 25 ppm N,N-diethylnitrosamine (DEN) in the drinking water induced lung and liver tumors in all mice by 25 weeks post treatment, compared to only about 44% of similarly treated wild-type mice
• treatment with a lower dose of DEN (0.05 ppm), which does not induce tumors in wild-type mice, induces liver or lung tumors in some mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory