All Phenotypes Jam3<tm1.1Chav> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Jam3^tm1.1Chav/Jam3^tm1.1Chav Tg(Tal1-cre/ERT)1Jrg/?	involves: 129 * C57BL/6	MGI:5140202
cn2	Jam3^tm1.1Chav/Jam3^tm1.2Chav Tg(Cdh5-cre)7Mlia/?	involves: 129 * C57BL/6 * FVB/N	MGI:5140203
cn3	Jam3^tm1Rha/Jam3^tm1.1Chav Tg(Spo11-cre)D5Mpel/0	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:5297584

Allelic Composition	Jam3^tm1.1Chav/Jam3^tm1.1Chav Tg(Tal1-cre/ERT)1Jrg/?
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jam3^tm1.1Chav mutation (0 available); any Jam3 mutation (24 available)
Tg(Tal1-cre/ERT)1Jrg mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased metastatic potential ( J:173391 )

• B16 cell transmigration is considerably reduced after treatment with 4-hydroxytamoxifen

• significantly reduced B16 melanoma lung metastasis after treatment with 4-hydroxytamoxifen

Allelic Composition	Jam3^tm1.1Chav/Jam3^tm1.2Chav Tg(Cdh5-cre)7Mlia/?
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jam3^tm1.1Chav mutation (0 available); any Jam3 mutation (24 available)
Jam3^tm1.2Chav mutation (0 available); any Jam3 mutation (24 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased metastatic potential ( J:173391 )

• significantly reduced B16 melanoma lung metastasis

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal spermatid morphology ( J:166888 )

• rare elongating spermatids are detected in tubules in the testis

• degenerating spermatids and spermatocytes are observed in seminiferous tubules

abnormal manchette morphology ( J:166888 )

• cytoskeletal defects are observed in round spermatids; F-actin appears uniformly distributed (disorganized) within the cytoplasm, not localized to restricted zones of the cells (polarized)

decreased male germ cell number ( J:166888 )

• from 2 months of age onward, males show a strong decrease in sperm number from 90 to 95% relative to control males

increased male germ cell apoptosis ( J:166888 )

• widespread germ cell apoptosis is observed in testes

small testis ( J:166888 )

• reduction in testis size is observed in analyses at 7 months of age

arrest of spermatogenesis ( J:166888 )

• more than 80-90% of tubules are arrested at round stage of spermatid differentiation

endocrine/exocrine glands