Phenotypes associated with this allele

• Allele Symbol: Angpt1^tm1.1Seq
• Allele Name: targeted mutation 1.1, Susan E Quaggin
• Allele ID: MGI:5140300
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Angpt1^tm1.1Seq/Angpt1^tm1.1Seq Angpt2^tm1c(KOMP)Seq/Angpt2^tm1c(KOMP)Seq Gt(ROSA)26Sor^tm1(rtTA,EGFP)Nagy/? Tg(tetO-cre)1Jaw/0	involves: 129 * C57BL/6NCr	MGI:5613965
cn2	Angpt1^tm1.1Seq/Angpt1^tm1.2Seq Tg(Nphs1-cre)1Seq/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5140326
cn3	Angpt1^tm1.1Seq/Angpt1^tm1.2Seq Tg(Pdgfrb-cre)#Rha/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5140327

Genotype
MGI:5613965

cn1

• Allelic Composition: Angpt1^tm1.1Seq/Angpt1^tm1.1Seq; Angpt2^{tm1c(KOMP)Seq}/Angpt2^{tm1c(KOMP)Seq}; Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/?; Tg(tetO-cre)1Jaw/0
• Genetic Background: involves: 129 * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cornea vascularization ( J:217296 )

• capillary loops extend into the cornea

vision/eye

abnormal eye morphology ( J:217296 )

• in mice exposed to deoxycycline treatment at E16.5

abnormal anterior eye segment morphology ( J:217296 )

absent Schlemm's canal ( J:217296 )

abnormal cornea morphology ( J:217296 )

• lymphatic vasculature develops in the corneal limbus

cornea vascularization ( J:217296 )

• capillary loops extend into the cornea

increased cornea size ( J:217296 )

• enlarged

increased eye anterior chamber depth ( J:217296 )

• increased anterior chamber depth

buphthalmos ( J:217296 )

• eyes begin to protrude by 21 to 28 days of age

• difficulty closing eyelids by 8 weeks of age

abnormal retina layer morphology ( J:217296 )

• reduced thickness of retinal cell layer

thin retina ganglion layer ( J:217296 )

thin retina inner nuclear layer ( J:217296 )

abnormal retina nerve fiber layer morphology ( J:217296 )

• reduced thickness

thin retina outer nuclear layer ( J:217296 )

• becoming worse toward periphery

abnormal eye physiology ( J:217296 )

• in mice exposed to deoxycycline treatment at E16.5

abnormal intraocular pressure ( J:217296 )

• elevated

decreased visual acuity ( J:217296 )

• severely impaired vision

immune system

abnormal lymphatic vessel morphology ( J:217296 )

• lymphatic vessels are sparse in the dermis of the ear

• abnormal branching of lymphatic vessels

Genotype
MGI:5140326

cn2

• Allelic Composition: Angpt1^tm1.1Seq/Angpt1^tm1.2Seq; Tg(Nphs1-cre)1Seq/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

renal/urinary system

abnormal renal glomerulus morphology ( J:174022 )

• mice treated with doxycycline since E16.5 and exposed to STZ to induce diabetes exhibit accelerated glomerular damage compared with similarly treated control mice

Genotype
MGI:5140327

cn3

• Allelic Composition: Angpt1^tm1.1Seq/Angpt1^tm1.2Seq; Tg(Pdgfrb-cre)#Rha/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

renal/urinary system

abnormal renal glomerulus morphology ( J:174022 )

• mice treated with doxycycline since E16.5 and exposed to STZ to induce diabetes exhibit accelerated glomerular damage compared with similarly treated control mice