About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Angpt1tm1.2Seq
targeted mutation 1.2, Susan E Quaggin
MGI:5140301
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Angpt1tm1.1Seq/Angpt1tm1.2Seq
Tg(Nphs1-cre)1Seq/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5140326
cn2
 		Angpt1tm1.1Seq/Angpt1tm1.2Seq
Tg(Pdgfrb-cre)#Rha/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5140327
cx3
 		Angpt1tm1.2Seq/Angpt1tm1.2Seq
Kdrtm2.1Jrt/Kdr+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5140325


Genotype
MGI:5140326
cn1
Allelic
Composition		 Angpt1tm1.1Seq/Angpt1tm1.2Seq
Tg(Nphs1-cre)1Seq/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angpt1tm1.1Seq mutation (0 available); any Angpt1 mutation (35 available)
Angpt1tm1.2Seq mutation (0 available); any Angpt1 mutation (35 available)
Tg(Nphs1-cre)1Seq mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal renal glomerulus morphology ( J:174022 )
• mice treated with doxycycline since E16.5 and exposed to STZ to induce diabetes exhibit accelerated glomerular damage compared with similarly treated control mice




Genotype
MGI:5140327
cn2
Allelic
Composition		 Angpt1tm1.1Seq/Angpt1tm1.2Seq
Tg(Pdgfrb-cre)#Rha/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angpt1tm1.1Seq mutation (0 available); any Angpt1 mutation (35 available)
Angpt1tm1.2Seq mutation (0 available); any Angpt1 mutation (35 available)
Tg(Pdgfrb-cre)#Rha mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal renal glomerulus morphology ( J:174022 )
• mice treated with doxycycline since E16.5 and exposed to STZ to induce diabetes exhibit accelerated glomerular damage compared with similarly treated control mice




Genotype
MGI:5140325
cx3
Allelic
Composition		 Angpt1tm1.2Seq/Angpt1tm1.2Seq
Kdrtm2.1Jrt/Kdr+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angpt1tm1.2Seq mutation (0 available); any Angpt1 mutation (35 available)
Kdrtm2.1Jrt mutation (2 available); any Kdr mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Loss of trabeculations in the heart of E9.5 and E10.5 Angpt1tm1.2Seq/Angpt1tm1.2Seq Kdrtm2.1Jrt/Kdr+ embryos

mortality/aging

cardiovascular system
abnormal brain vasculature morphology ( J:174022 )
• at E10.5, mice exhibit an increase in vasculature in the hindbrain compared with wild-type mice
abnormal vascular development ( J:174022 )
• at E10.5, mice exhibit vascular defects with fusion of large diameter vessels and absence of patterning compared with wild-type mice
• however, pericyte coverage is normal
abnormal heart development ( J:174022 )
• at E 9.5, mice exhibit heart defects and loss of heart trabeculation unlike wild-type mice

embryo

nervous system
abnormal brain vasculature morphology ( J:174022 )
• at E10.5, mice exhibit an increase in vasculature in the hindbrain compared with wild-type mice

growth/size/body
decreased embryo size ( J:174022 )
• at E10.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory