Phenotypes associated with this allele

• Allele Symbol: Tex19.1^{tm1(rtTA2S*M2,lacZ)Jw}
• Allele Name: targeted mutation 1, Jeremy Wang
• Allele ID: MGI:5140347
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tex19.1^tm1(rtTA2S*M2,lacZ)Jw/Tex19.1^tm1(rtTA2S*M2,lacZ)Jw	involves: 129S4/SvJae * C57BL/6	MGI:5140348

Genotype
MGI:5140348

hm1

• Allelic Composition: Tex19.1^{tm1(rtTA2S*M2,lacZ)Jw}/Tex19.1^{tm1(rtTA2S*M2,lacZ)Jw}
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:166982 )

• significant nreduction in homozygotes identified

• presumed embryonic lethality

• particularly of females

reproductive system

abnormal chiasmata formation ( J:166982 )

• normal synapses in about 48% of spermatocytes and variable extent to which synapses fail to form in the remaining spermatocytes

arrest of male meiosis ( J:166982 )

♂ • spermatogenesis blocked in meiosis

♂ • abundant zygotene and early pachytene spermatocytes but few post meiotic germ cells

♂ • variable from mouse to mouse and from tubule to tubule

small testis ( J:166982 )

♂ • sharply reduced testis size

endocrine/exocrine glands

small testis ( J:166982 )

♂ • sharply reduced testis size

cellular

abnormal chiasmata formation ( J:166982 )

• normal synapses in about 48% of spermatocytes and variable extent to which synapses fail to form in the remaining spermatocytes

arrest of male meiosis ( J:166982 )

♂ • spermatogenesis blocked in meiosis

♂ • abundant zygotene and early pachytene spermatocytes but few post meiotic germ cells

♂ • variable from mouse to mouse and from tubule to tubule