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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Dct-lacZ)#Ove
transgene insertion, Paul A Overbeek
MGI:5140350
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ednrbtm1Nrd/Ednrbtm1Nrd
Tg(Dct-lacZ)#Ove/0
Tg(Tyr-cre/ERT2)13Bos/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N MGI:6269406
cn2
 		Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(CMV-cre)1Cgn/0
Tg(Dct-lacZ)#Ove/0 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB/N MGI:6269442
cn3
 		Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(Dct-lacZ)#Ove/0
Tg(Tyr-cre/ERT2)13Bos/0 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB/N MGI:6269447
cn4
 		Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(Dct-lacZ)#Ove/0
Tg(Krt1-15-cre/PGR*)22Cot/0 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB/N * SJL/J MGI:6269449
cx5
 		Rpl27aSfa/Rpl27a+
Tg(Dct-lacZ)#Ove/0 		involves: C57BL/6J * FVB/N MGI:5140358


Genotype
MGI:6269406
cn1
Allelic
Composition		 Ednrbtm1Nrd/Ednrbtm1Nrd
Tg(Dct-lacZ)#Ove/0
Tg(Tyr-cre/ERT2)13Bos/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbtm1Nrd mutation (1 available); any Ednrb mutation (104 available)
Tg(Dct-lacZ)#Ove mutation (0 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal epidermal melanocyte morphology ( J:231435 )
• following TAM treatment immediately after wounding at 8 weeks of age, mice show a significantly reduced number of epidermal melanocytes in the wound area both at day 0 and day 8 after re- epithelialization relative to control mice
• however, no signs of apoptosis are observed, suggesting normal survival of epidermal melanocytes after wounding
decreased melanocyte number ( J:231435 )
• following initial TAM treatment during 2nd anagen, the number of Dct-LacZ+ melanocyte stem cells (McSCs) in unpigmented hair follicles is significantly lower than that in control mice by the 2nd telogen; most unpigmented hair follicles completely lack McSCs by the 3rd and 4th telogen

integument
abnormal epidermal melanocyte morphology ( J:231435 )
• following TAM treatment immediately after wounding at 8 weeks of age, mice show a significantly reduced number of epidermal melanocytes in the wound area both at day 0 and day 8 after re- epithelialization relative to control mice
• however, no signs of apoptosis are observed, suggesting normal survival of epidermal melanocytes after wounding




Genotype
MGI:6269442
cn2
Allelic
Composition		 Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(CMV-cre)1Cgn/0
Tg(Dct-lacZ)#Ove/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation (1 available); any Mc1r mutation (44 available)
Tg(CMV-cre)1Cgn mutation (6 available)
Tg(Dct-lacZ)#Ove mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal epidermal melanocyte morphology ( J:231435 )
• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice

integument
abnormal epidermal melanocyte morphology ( J:231435 )
• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice




Genotype
MGI:6269447
cn3
Allelic
Composition		 Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(Dct-lacZ)#Ove/0
Tg(Tyr-cre/ERT2)13Bos/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation (1 available); any Mc1r mutation (44 available)
Tg(Dct-lacZ)#Ove mutation (0 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal epidermal melanocyte morphology ( J:231435 )
• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice

integument
abnormal epidermal melanocyte morphology ( J:231435 )
• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice




Genotype
MGI:6269449
cn4
Allelic
Composition		 Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(Dct-lacZ)#Ove/0
Tg(Krt1-15-cre/PGR*)22Cot/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB/N * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation (1 available); any Mc1r mutation (44 available)
Tg(Dct-lacZ)#Ove mutation (0 available)
Tg(Krt1-15-cre/PGR*)22Cot mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:231435 )
N
• following wounding, mice show no differences in the recruitment of epidermal melanocytes to the wound area relative to control mice




Genotype
MGI:5140358
cx5
Allelic
Composition		 Rpl27aSfa/Rpl27a+
Tg(Dct-lacZ)#Ove/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpl27aSfa mutation (0 available); any Rpl27a mutation (52 available)
Tg(Dct-lacZ)#Ove mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal epidermal melanocyte morphology ( J:174216 )
• dramatic increase in epidermal melanocyte numbers with increased deposition of melanin granules in the foot pads and tail
hyperpigmentation ( J:174216 )
• dramatic increase in epidermal melanocyte numbers with increased deposition of melanin granules
increased tail pigmentation ( J:174216 )
• hyperpigmentation of the tail

integument
abnormal epidermal melanocyte morphology ( J:174216 )
• dramatic increase in epidermal melanocyte numbers with increased deposition of melanin granules in the foot pads and tail
increased tail pigmentation ( J:174216 )
• hyperpigmentation of the tail

limbs/digits/tail
increased tail pigmentation ( J:174216 )
• hyperpigmentation of the tail




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory