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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbx21tm2Srnr
targeted mutation 2, Steven L Reiner
MGI:5140531
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tbx21tm2Srnr/Tbx21tm2Srnr
Tg(Cd4-cre)1Cwi/0 		involves: 129 * C57BL/6 * DBA/2 MGI:5140535
cn2
 		Tbx21tm2Srnr/Tbx21+
Tg(Cd4-cre)1Cwi/0 		involves: 129 * C57BL/6 * DBA/2 MGI:5140536


Genotype
MGI:5140535
cn1
Allelic
Composition		 Tbx21tm2Srnr/Tbx21tm2Srnr
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx21tm2Srnr mutation (1 available); any Tbx21 mutation (37 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:137655 )
N
• type 17 differentiation of virus-specific CD8+ T cells is normal
decreased CD8-positive, alpha-beta T cell number ( J:174315 )
• 8 and 30 days after LCMV infection, mice exhibit fewer antigen-specific CD8+ T cells in the spleen and other tissues compared with wild-type mice
increased interleukin-17 secretion ( J:174315 )
• in CD8+ T cells of LCMV-infected mice and restimulated cells
increased interleukin-2 secretion ( J:174315 )
• in CD8+ T cells of LCMV-infected mice and restimulated cells
increased tumor necrosis factor secretion ( J:174315 )
• in CD8+ T cells of LCMV-infected mice and restimulated cells
increased susceptibility to Riboviria infection ( J:174315 )
• LCMV-infected mice exhibit decreased antigen-specific CD8+ T cells, increased viral load in the blood, and increased CD8+ T cell production of IL2, TNF, and IL17 compared with wild-type mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:174315 )
• 8 and 30 days after LCMV infection, mice exhibit fewer antigen-specific CD8+ T cells in the spleen and other tissues compared with wild-type mice




Genotype
MGI:5140536
cn2
Allelic
Composition		 Tbx21tm2Srnr/Tbx21+
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx21tm2Srnr mutation (1 available); any Tbx21 mutation (37 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:174315 )
• 30 days after LCMV infection, mice exhibit fewer antigen-specific CD8+ T cells in the bone marrow compared with wild-type mice
increased susceptibility to Riboviria infection ( J:174315 )
• LCMV-infected mice exhibit decreased antigen-specific CD8+ T cells and increased viral load in the blood after 60 days compared with wild-type mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:174315 )
• 30 days after LCMV infection, mice exhibit fewer antigen-specific CD8+ T cells in the bone marrow compared with wild-type mice




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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory