vision/eye
• at 3 to 4 months, mice exhibit slow progressive retinal degeneration unlike in wild-type mice
• however, early adult mice do not exhibit degeneration
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• mice exhibit increased half-saturating light intensity and decreased time to peak, integration time, time constant of single-exponential decay of dim flash response recovery phase, and dominant time constant of recovery after saturating flashes compared with wild-type mice
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• at 2 months, scotopic visual sensitivity is reduced compared to in wild-type mice
• scotopic spatial contrast sensitivity is shifted 100-fold to brighter light conditions compared to in wild-type mice
• a-wave sensitivity is decreased 33-fold and maximal amplitude is decreased 2-fold compared to in wild-type mice
• the amplitude of scotopic b-wave is decreased and b-wave sensitivity is decreased 38-fold compared with wild-type mice
• rod light sensitivity is decreased 90-fold compared to in wild-type rods
• rising phase rod response requires a 40-fold increase in flash strength compared with wild-type rods
• phototransduction amplification is reduced 33-fold compared with to in wild-type mice
• the inactivation rate of dim flash photoresponse is accelerated compared to in wild-type mice
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