Analysis Tools
nervous system
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• mice treated with DZP and a low concentration of muscimol fail to exhibit a drop in the rate of successful transmission unlike similarly treated wild-type mice
• DZP-potentiated dorsal root potential is strongly reduced compared to in wild-type mice
• however, bicuculline-induced dorsal root potential size and sensitivity
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• the amplitudes of GABAergic membrane currents evoked by DZP are reduced compared to in wild-type mice
• however, muscimol induces normal amplitudes of GABAergic membrane currents
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behavior/neurological
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• DZP-treated mice exhibit a reduction in the antihyperalgesia effect on inflammatory thermal and mechanical hyperalgesia compared with similarly treated wild-type mice that is not as severe as in Gabra2tm1Uru/Gabra2tm1Uru Tg(Scn10a-cre)1Rkun
• however, DZP-induced analgesia of neuropathic thermal and mechanical nociception is normal
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homeostasis/metabolism
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• diazepam (DZP)-treated mice exhibit a reduction in the antihyperalgesia effect on inflammatory thermal and mechanical hyperalgesia compared with similarly treated wild-type mice that is not as severe as in Gabra2tm1Uru/Gabra2tm1Uru Tg(Scn10a-cre)1Rkun
• however, DZP-induced analgesia of neuropathic thermal and mechanical nociception is normal
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