Analysis Tools
cellular
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• cultured pro T-cells exhibit an increased susceptibility to apoptosis as compared to wild-type
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• T cell proliferation is decreased in response to anti-CD3 plus IL7, however, proliferation is similar to wild-type when induced with anti-CD3 plus IL2
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hematopoietic system
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• cultured pro T-cells exhibit an increased susceptibility to apoptosis as compared to wild-type
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• T cell proliferation is decreased in response to anti-CD3 plus IL7, however, proliferation is similar to wild-type when induced with anti-CD3 plus IL2
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• transgene expression restores thymic cellularity to 74% from 6% found in nontransgenic homozygous Il7rtm1Imx mice; expression is not restored on bone marrow thymocytes or CD43- B220+ B lineage cells
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immune system
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• cultured pro T-cells exhibit an increased susceptibility to apoptosis as compared to wild-type
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• T cell proliferation is decreased in response to anti-CD3 plus IL7, however, proliferation is similar to wild-type when induced with anti-CD3 plus IL2
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• transgene expression restores thymic cellularity to 74% from 6% found in nontransgenic homozygous Il7rtm1Imx mice; expression is not restored on bone marrow thymocytes or CD43- B220+ B lineage cells
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endocrine/exocrine glands
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• cultured pro T-cells exhibit an increased susceptibility to apoptosis as compared to wild-type
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• transgene expression restores thymic cellularity to 74% from 6% found in nontransgenic homozygous Il7rtm1Imx mice; expression is not restored on bone marrow thymocytes or CD43- B220+ B lineage cells
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