Phenotypes associated with this allele

• Allele Symbol: Ccdc88a^tm2.1Mat
• Allele Name: targeted mutation 2.1, Masahide Takahashi
• Allele ID: MGI:5140603
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccdc88a^tm2.1Mat/Ccdc88a^tm2.1Mat	involves: 129S6/SvEvTac * C57BL/6	MGI:5140720

Genotype
MGI:5140720

hm1

• Allelic Composition: Ccdc88a^tm2.1Mat/Ccdc88a^tm2.1Mat
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dendritic spine morphology ( J:217412 )

• dentate granule cells exhibit thinner spines accompanied by a small volume and shortened spine head diameter

• however, dentate granule cell spine density is normal

reduced sensorimotor gating ( J:217412 )

• mice show impaired sensorimotor gating as indicated by pre-pulse inhibition deficits without changes in the acoustic startle amplitude

abnormal excitatory postsynaptic currents ( J:217412 )

• the ratio of excitatory postsynaptic currents (EPSCs) mediated by NMDA receptor to AMPA receptor in dentate granule cells of hippocampal slices is lower

• however, mice show a normal decay time constant of NMDA receptor-mediated EPSCs

reduced long-term potentiation ( J:217412 )

• magnitude of LTP is smaller at 55-60 min after the TET in the hippocampus

• however, synaptic transmission at the medial perforant path-dentate granule cell synapses is normal

decreased prepulse inhibition ( J:217412 )

• pre-pulse inhibition deficits without changes in the acoustic startle amplitude

behavior/neurological

impaired contextual conditioning behavior ( J:217412 )

• in the fear conditioning test, 7-20 week old mice show context-dependent fear memory impairment 24 hours, but not 1 hour, after fear conditioning, although no difference is seen in freezing time in the conditioning phase

• mice show impairment of tone-dependent freezing 24 hours after the conditioning

• however, stimulus thresholds of electric footshock for vocalization are normal

abnormal habituation to a new environment ( J:217412 )

• mice show an increase in exploratory activity during the last 30 min of activity in a novel environment, suggesting impaired habituation to a novel environment

• mice, however, show normal behavior in the open field, elevated-plus maze, forced-swimming, and sucrose-preference tests

impaired long-term object recognition memory ( J:217412 )

• in the novel object recognition test, mice show a decrease in the exploratory preference for novel objects in the retention session performed 24 hours after the training session

impaired spatial learning ( J:217412 )

• in the Morris water maze, mice take a longer path length to find the hidden platform during training trails, however no difference is seen in the visible test on day 7 and in the swimming velocity during the training trials

• mice, howerver, show normal short-term memory in the Y-maze test

growth/size/body

growth/size/body region phenotype ( J:173379 )

N • mice exhibit normal growth

mortality/aging

mortality/aging ( J:173379 )

N • mice exhibit normal survival