Phenotypes associated with this allele

• Allele Symbol: F2^tm2Jld
• Allele Name: targeted mutation 2, Jay L Degen
• Allele ID: MGI:5140722
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	F2^tm2Jld/F2^tm2Jld	B6.129P2-F2^tm2Jld	MGI:5140787
ht2	F2^tm2Jld/F2^+	B6.129P2-F2^tm2Jld	MGI:5140788
ht3	F2^tm2Jld/F2^+	involves: 129P2/OlaHsd * C57BL/6 * DBA/2J	MGI:5140789

Genotype
MGI:5140787

hm1

• Allelic Composition: F2^tm2Jld/F2^tm2Jld
• Genetic Background: B6.129P2-F2^tm2Jld

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:174629 )

• some mice die between a few days of birth and remaining mice die within 2 weeks

integument

subcutaneous hemorrhage ( J:174629 )

• subcutaneous bleeding within the head and neck region

cardiovascular system

internal hemorrhage ( J:174629 )

• overt hemorrhage in the abdomen

subcutaneous hemorrhage ( J:174629 )

• subcutaneous bleeding within the head and neck region

Genotype
MGI:5140788

ht2

• Allelic Composition: F2^tm2Jld/F2⁺
• Genetic Background: B6.129P2-F2^tm2Jld

homeostasis/metabolism

abnormal circulating protein level ( J:174629 )

• LPS-treated mice exhibit a modest decrease in activated protein C serum and thrombin-antithrombin levels compared with similarly treated wild-type mice

decreased susceptibility to induced thrombosis ( J:174629 )

• following FeCl3 injury, mice exhibit extended time to complete vessel occlusion compared with similarly treated wild-type mice

increased bleeding time ( J:174629 )

immune system

decreased susceptibility to endotoxin shock ( J:174629 )

• LPS-treated mice exhibit a modest decrease in activated protein C serum and thrombin-antithrombin levels compared with similarly treated wild-type mice

• however, LPS-treated mice exhibit no survival advantage

Genotype
MGI:5140789

ht3

• Allelic Composition: F2^tm2Jld/F2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

immune system

decreased susceptibility to induced arthritis ( J:174629 )

• mice treated with collagen to induce arthritis exhibit reduced histologic features of inflammatory joint disease (inflammatory cell infiltrate, synovial hyperplasia, edema, pannus formation, and cartilage/bone degradation) compared with similarly treated wild-type mice

skeleton

decreased susceptibility to induced arthritis ( J:174629 )

• mice treated with collagen to induce arthritis exhibit reduced histologic features of inflammatory joint disease (inflammatory cell infiltrate, synovial hyperplasia, edema, pannus formation, and cartilage/bone degradation) compared with similarly treated wild-type mice