Phenotypes associated with this allele

• Allele Symbol: Fezf1^tm1.1Bche
• Allele Name: targeted mutation 1.1, Bin Chen
• Allele ID: MGI:5140793
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fezf1^tm1.1Bche/Fezf1^tm1.1Bche	involves: CD-1	MGI:5140794
cx2	Fezf1^tm1.1Bche/Fezf1^tm1.1Bche Fezf2^tm1Skm/Fezf2^tm1Skm	involves: 129 * CD-1	MGI:5140795
cx3	Fezf1^tm1.1Bche/Fezf1^+ Fezf2^tm1Skm/Fezf2^tm1Skm	involves: 129 * CD-1	MGI:5140796

Genotype
MGI:5140794

hm1

• Allelic Composition: Fezf1^tm1.1Bche/Fezf1^tm1.1Bche
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal olfactory sensory neuron morphology ( J:174726 )

• olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

craniofacial

abnormal olfactory sensory neuron morphology ( J:174726 )

• olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

respiratory system

abnormal olfactory sensory neuron morphology ( J:174726 )

• olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:174726 )

• olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

growth/size/body

abnormal olfactory sensory neuron morphology ( J:174726 )

• olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

Genotype
MGI:5140795

cx2

• Allelic Composition: Fezf1^tm1.1Bche/Fezf1^tm1.1Bche; Fezf2^tm1Skm/Fezf2^tm1Skm
• Genetic Background: involves: 129 * CD-1

nervous system

abnormal vomeronasal sensory neuron morphology ( J:174726 )

• mice lack vomeronasal organ neurons unlike wild-type mice

absent vomeronasal organ ( J:174726 )

• at P0, the vomeronasal organ is absent unlike in wild-type mice

• mice exhibit vomeronasal organ degeneration compared with wild-type mice

abnormal olfactory sensory neuron morphology ( J:174726 )

• as in Fezf1^tm1.1Bche homozygotes, olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

craniofacial

abnormal vomeronasal sensory neuron morphology ( J:174726 )

• mice lack vomeronasal organ neurons unlike wild-type mice

absent vomeronasal organ ( J:174726 )

• at P0, the vomeronasal organ is absent unlike in wild-type mice

• mice exhibit vomeronasal organ degeneration compared with wild-type mice

abnormal olfactory sensory neuron morphology ( J:174726 )

• as in Fezf1^tm1.1Bche homozygotes, olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

respiratory system

abnormal vomeronasal sensory neuron morphology ( J:174726 )

• mice lack vomeronasal organ neurons unlike wild-type mice

absent vomeronasal organ ( J:174726 )

• at P0, the vomeronasal organ is absent unlike in wild-type mice

• mice exhibit vomeronasal organ degeneration compared with wild-type mice

abnormal olfactory sensory neuron morphology ( J:174726 )

• as in Fezf1^tm1.1Bche homozygotes, olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:174726 )

• as in Fezf1^tm1.1Bche homozygotes, olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

growth/size/body

abnormal vomeronasal sensory neuron morphology ( J:174726 )

• mice lack vomeronasal organ neurons unlike wild-type mice

absent vomeronasal organ ( J:174726 )

• at P0, the vomeronasal organ is absent unlike in wild-type mice

• mice exhibit vomeronasal organ degeneration compared with wild-type mice

abnormal olfactory sensory neuron morphology ( J:174726 )

• as in Fezf1^tm1.1Bche homozygotes, olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

Genotype
MGI:5140796

cx3

• Allelic Composition: Fezf1^tm1.1Bche/Fezf1⁺; Fezf2^tm1Skm/Fezf2^tm1Skm
• Genetic Background: involves: 129 * CD-1

nervous system

abnormal vomeronasal sensory neuron morphology ( J:174726 )

• mice lack vomeronasal organ neurons unlike wild-type mice

absent vomeronasal organ ( J:174726 )

• at P0, the vomeronasal organ is absent unlike in wild-type mice

small vomeronasal organ ( J:174726 )

• at E13.5, the vomeronasal organ is smaller than in wild-type mice

craniofacial

abnormal vomeronasal sensory neuron morphology ( J:174726 )

• mice lack vomeronasal organ neurons unlike wild-type mice

absent vomeronasal organ ( J:174726 )

• at P0, the vomeronasal organ is absent unlike in wild-type mice

small vomeronasal organ ( J:174726 )

• at E13.5, the vomeronasal organ is smaller than in wild-type mice

respiratory system

abnormal vomeronasal sensory neuron morphology ( J:174726 )

• mice lack vomeronasal organ neurons unlike wild-type mice

absent vomeronasal organ ( J:174726 )

• at P0, the vomeronasal organ is absent unlike in wild-type mice

small vomeronasal organ ( J:174726 )

• at E13.5, the vomeronasal organ is smaller than in wild-type mice

growth/size/body

abnormal vomeronasal sensory neuron morphology ( J:174726 )

• mice lack vomeronasal organ neurons unlike wild-type mice

absent vomeronasal organ ( J:174726 )

• at P0, the vomeronasal organ is absent unlike in wild-type mice

small vomeronasal organ ( J:174726 )

• at E13.5, the vomeronasal organ is smaller than in wild-type mice