Phenotypes associated with this allele

• Allele Symbol: Bcl6^tm1.1Toka
• Allele Name: targeted mutation 1.1, Takaharu Okada
• Allele ID: MGI:5140802
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcl6^tm1.1Toka/Bcl6^tm1.1Toka	involves: C57BL/6 * NZB	MGI:5140807
cx2	Bcl6^tm1.1Toka/Bcl6^+ Tg(TcraTcrb)425Cbn/0	involves: BALB/c * C57BL/6 * NZB	MGI:5140808
cx3	Bcl6^tm1.1Toka/Bcl6^tm1.1Toka Tg(IghelMD4)4Ccg/0	involves: C57BL/6 * NZB	MGI:5140809

Genotype
MGI:5140807

hm1

• Allelic Composition: Bcl6^tm1.1Toka/Bcl6^tm1.1Toka
• Genetic Background: involves: C57BL/6 * NZB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:174014 )

N • antibody class switching is normal

decreased germinal center B cell number ( J:174014 )

decreased T follicular helper cell number ( J:174014 )

• in Peyer's patches

abnormal Peyer's patch morphology ( J:174014 )

• Peyer's patches contain fewer T follicular helper cells compared to in wild-type mice

hematopoietic system

decreased germinal center B cell number ( J:174014 )

decreased T follicular helper cell number ( J:174014 )

• in Peyer's patches

Genotype
MGI:5140808

cx2

• Allelic Composition: Bcl6^tm1.1Toka/Bcl6⁺; Tg(TcraTcrb)425Cbn/0
• Genetic Background: involves: BALB/c * C57BL/6 * NZB

immune system

decreased T cell proliferation ( J:174014 )

• T follicular helper cells in mice immunized with NP-ovalbumin exhibit accelerated proliferatively quiescent unlike wild-type cells

hematopoietic system

decreased T cell proliferation ( J:174014 )

• T follicular helper cells in mice immunized with NP-ovalbumin exhibit accelerated proliferatively quiescent unlike wild-type cells

cellular

decreased T cell proliferation ( J:174014 )

• T follicular helper cells in mice immunized with NP-ovalbumin exhibit accelerated proliferatively quiescent unlike wild-type cells

Genotype
MGI:5140809

cx3

• Allelic Composition: Bcl6^tm1.1Toka/Bcl6^tm1.1Toka; Tg(IghelMD4)4Ccg/0
• Genetic Background: involves: C57BL/6 * NZB

immune system

increased activation-induced B cell apoptosis ( J:174014 )

• B cells co-transferred with Tg(TcraTcrb)425Cbn cells into wild-type mice immunized with HEL-ovalbumin exhibit increased apoptosis compared with similarly treated heterozygous cells

abnormal germinal center B cell physiology ( J:174014 )

• B cells co-transferred with Tg(TcraTcrb)425Cbn cells into wild-type mice immunized with HEL-ovalbumin exhibit impaired formation of germinal center B cell populations compared with similarly treated heterozygous cells

cellular

increased activation-induced B cell apoptosis ( J:174014 )

• B cells co-transferred with Tg(TcraTcrb)425Cbn cells into wild-type mice immunized with HEL-ovalbumin exhibit increased apoptosis compared with similarly treated heterozygous cells

hematopoietic system

increased activation-induced B cell apoptosis ( J:174014 )

• B cells co-transferred with Tg(TcraTcrb)425Cbn cells into wild-type mice immunized with HEL-ovalbumin exhibit increased apoptosis compared with similarly treated heterozygous cells

abnormal germinal center B cell physiology ( J:174014 )

• B cells co-transferred with Tg(TcraTcrb)425Cbn cells into wild-type mice immunized with HEL-ovalbumin exhibit impaired formation of germinal center B cell populations compared with similarly treated heterozygous cells