Phenotypes associated with this allele

• Allele Symbol: Fezf1^tm1Taku
• Allele Name: targeted mutation 1, Toru Takumi
• Allele ID: MGI:5140810
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fezf1^tm1Taku/Fezf1^tm1Taku	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5140834

Genotype
MGI:5140834

hm1

• Allelic Composition: Fezf1^tm1Taku/Fezf1^tm1Taku
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:174482 )

• die within 1 day of birth

nervous system

abnormal axon extension ( J:174482 )

• cultured olfactory neurons are shortened and lack complex growth cones

abnormal olfactory sensory neuron morphology ( J:174482 )

• olfactory axons terminate in a tangles fibrocellular mass between the olfactory bulb and the cribriform plate

• olfactory projections to the olfactory bulb are absent

• few olfactory axons in contact with the CNS basal lamina at E10.5

• "migratory mass" is disintegrating at E11.5 and few axons have reached the basal lamina

• no axons penetrate the basal lamina at E12.5

• olfactory neurons co-cultured with olfactory bulb successfully "project" to the olfactory bulb if no meningeal tissue is present

small olfactory bulb ( J:174482 )

• smaller than controls at birth

growth/size/body

abnormal olfactory sensory neuron morphology ( J:174482 )

• olfactory axons terminate in a tangles fibrocellular mass between the olfactory bulb and the cribriform plate

• olfactory projections to the olfactory bulb are absent

• few olfactory axons in contact with the CNS basal lamina at E10.5

• "migratory mass" is disintegrating at E11.5 and few axons have reached the basal lamina

• no axons penetrate the basal lamina at E12.5

• olfactory neurons co-cultured with olfactory bulb successfully "project" to the olfactory bulb if no meningeal tissue is present

distended abdomen ( J:174482 )

• swollen abdomen in 11 of 12 pups examined

• stomach and intestine filled with air

behavior/neurological

abnormal reflex ( J:174482 )

• tend to begin hiccoughing after ingesting milk

cellular

abnormal axon extension ( J:174482 )

• cultured olfactory neurons are shortened and lack complex growth cones

craniofacial

abnormal olfactory sensory neuron morphology ( J:174482 )

• olfactory axons terminate in a tangles fibrocellular mass between the olfactory bulb and the cribriform plate

• olfactory projections to the olfactory bulb are absent

• few olfactory axons in contact with the CNS basal lamina at E10.5

• "migratory mass" is disintegrating at E11.5 and few axons have reached the basal lamina

• no axons penetrate the basal lamina at E12.5

• olfactory neurons co-cultured with olfactory bulb successfully "project" to the olfactory bulb if no meningeal tissue is present

respiratory system

abnormal olfactory sensory neuron morphology ( J:174482 )

• olfactory axons terminate in a tangles fibrocellular mass between the olfactory bulb and the cribriform plate

• olfactory projections to the olfactory bulb are absent

• few olfactory axons in contact with the CNS basal lamina at E10.5

• "migratory mass" is disintegrating at E11.5 and few axons have reached the basal lamina

• no axons penetrate the basal lamina at E12.5

• olfactory neurons co-cultured with olfactory bulb successfully "project" to the olfactory bulb if no meningeal tissue is present

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:174482 )

• olfactory axons terminate in a tangles fibrocellular mass between the olfactory bulb and the cribriform plate

• olfactory projections to the olfactory bulb are absent

• few olfactory axons in contact with the CNS basal lamina at E10.5

• "migratory mass" is disintegrating at E11.5 and few axons have reached the basal lamina

• no axons penetrate the basal lamina at E12.5

• olfactory neurons co-cultured with olfactory bulb successfully "project" to the olfactory bulb if no meningeal tissue is present