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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gna12tm1.1Cgh
targeted mutation 1.1, Shaun R Coughlin
MGI:5140818
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gna12tm1.1Cgh/Gna12tm1.1Cgh
Gna13tm2Cgh/Gna13tm2Cgh
Tg(Mx1-cre)1Cgn/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:5140845


Genotype
MGI:5140845
cn1
Allelic
Composition		 Gna12tm1.1Cgh/Gna12tm1.1Cgh
Gna13tm2Cgh/Gna13tm2Cgh
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1.1Cgh mutation (0 available); any Gna12 mutation (23 available)
Gna13tm2Cgh mutation (0 available); any Gna13 mutation (12 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell apoptosis ( J:174313 )
• in pIpC-treated mice
abnormal germinal center B cell morphology ( J:174313 )
• germinal center B cells in pIpC-treated mice exhibit a tendency to segregate from wild-type germinal center B cells
increased germinal center B cell number ( J:174313 )
• in mucosal germinal centers when bone marrow cells are used to reconstitute wild-type mice treated with pIpC

hematopoietic system
decreased B cell apoptosis ( J:174313 )
• in pIpC-treated mice
abnormal germinal center B cell morphology ( J:174313 )
• germinal center B cells in pIpC-treated mice exhibit a tendency to segregate from wild-type germinal center B cells
increased germinal center B cell number ( J:174313 )
• in mucosal germinal centers when bone marrow cells are used to reconstitute wild-type mice treated with pIpC

cellular
decreased B cell apoptosis ( J:174313 )
• in pIpC-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory