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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vasntm1Zgl
targeted mutation 1, Zhenggang Liu
MGI:5140849
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Vasntm1Zgl/Vasntm1Zgl B6.Cg-Vasntm1Zgl MGI:5140853
cx2
 		Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Vasntm1Zgl/Vasntm1Zgl 		involves: C57BL/6 MGI:5140854


Genotype
MGI:5140853
hm1
Allelic
Composition		 Vasntm1Zgl/Vasntm1Zgl
Genetic
Background		 B6.Cg-Vasntm1Zgl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vasntm1Zgl mutation (0 available); any Vasn mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:173568 )
• in mice treated with D-galactosamine (GalN) and TNFalpha

reproductive system
abnormal male germ cell apoptosis ( J:173568 )
• in mice treated with D-galactosamine (GalN) and TNFalpha

cellular
increased sensitivity to induced cell death ( J:173568 )
• in mouse embryonic fibroblasts treated with TNFalpha, cycloheximide (CHX), or CoCl2 (a chemical inducer of HIF-1)
• however, treatment with reactive oxygen species scavengers prevents induced cell death
increased cellular sensitivity to hydrogen peroxide ( J:173568 )
• in mouse embryonic fibroblasts
abnormal male germ cell apoptosis ( J:173568 )
• in mice treated with D-galactosamine (GalN) and TNFalpha
increased apoptosis ( J:173568 )
• mice treated with D-galactosamine (GalN) and TNFalpha exhibit increased apoptosis in the liver and testes compared with similarly treated wild-type mice
increased hepatocyte apoptosis ( J:173568 )
• in mice treated with D-galactosamine (GalN) and TNFalpha
oxidative stress ( J:173568 )
• mouse embryonic fibroblasts treated with TNFalpha plus cycloheximide (CHX), and CoCl2 (a chemical inducer of HIF-1) exhibit increased reactive oxygen species compared with similarly treated wild-type cells

liver/biliary system
increased hepatocyte apoptosis ( J:173568 )
• in mice treated with D-galactosamine (GalN) and TNFalpha

homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:173568 )
• in mice treated with D-galactosamine (GalN) and TNFalpha




Genotype
MGI:5140854
cx2
Allelic
Composition		 Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Vasntm1Zgl/Vasntm1Zgl
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Imx mutation (6 available); any Tnfrsf1a mutation (52 available)
Vasntm1Zgl mutation (0 available); any Vasn mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:173568 )
N
• male mice exhibit normal fertility and no abnormal male germ cell apoptosis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory