Analysis Tools|
Allele Symbol Allele Name Allele ID |
Pdgfrbtm14(Pdgfrb)Sor targeted mutation 14, Philippe Soriano MGI:5140883 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• authors state that the postnatal phenotype is indistinguishable from epiblast-specific cre activation of the floxed allele
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• authors state that the postnatal phenotype is indistinguishable from epiblast-specific cre activation of the floxed allele
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• usually by P14
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• during the second week
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• usually by P14
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• during the second week, mice exhibit thickening of the ascending aorta compared with wild-type mice
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| N |
• at P13, mice exhibit normal interscapular brown adipose tissue
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• at P13, inguinal white adipose tissue contains reduced lipids but higher cell density compared to in wild-type mice
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• at P13, only rudimentary mesenteric adipose depots are detected compared to in wild-type mice
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• at P9, white adipose tissue exhibit a 1.5-fold increase in the stromal vascular fraction compared with wild-type tissue
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• subcutaneous mesenchymal cells exhibit reduced white adipocyte differentiation in vitro compared with wild-type cells
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• at P13, inguinal and subcutaneous white adipose tissues contain reduced lipids but higher cell density compared to in wild-type mice
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• at P13, subcutaneous white adipose tissue contains reduced lipids but higher cell density compared to in wild-type mice
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• during the second week
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• at P13, subcutaneous white adipose tissue contains reduced lipids but higher cell density compared to in wild-type mice
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• subcutaneous mesenchymal cells exhibit reduced white adipocyte differentiation in vitro compared with wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal survival
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• mice exhibit alterations in the ascending aorta at 2 weeks that progresses through the arch and descending aorta to affect the entire thoracic and abdominal aorta by 4 weeks unlike in wild-type mice
• mice exhibit reduced periaortic adipose compared to in wild-type mice
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• thickened
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• authors state that mice exhibit the aorta phenotype observed in mice expressing the floxed allele and Tg(Sox2-cre)1Amc
• however, aorta histology is normal in neonates
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• by 4 weeks
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• by 4 weeks
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• by 4 weeks
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• by 4 weeks
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• increased radius
• 2-fold dilation that reaches homeostasis without rupture or apoptosis of vascular smooth muscle cells
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• at P7, retinal capillary size is increased compared to in wild-type mice
• at P12, brain capillary size is increased compared to in wild-type mice
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• reduced vessel density
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• reduced vessel density
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• pericyte coverage of brain and retinal vasculature is increased compared to in wild-type mice
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• mice exhibit increased vascular smooth muscle cell cellularity within the aorta compared with wild-type mice
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• at E18.5, mice exhibit increased vascular smooth muscle cell (VSMC) proliferation in the aorta compared with wild-type mice
• cultured aorta release >4-fold more VSMCs due to increased proliferation compared with wild-type cultures
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• mice exhibit reduced periaortic adipose compared to in wild-type mice
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| N |
• mice exhibit normal growth
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• mice exhibit increased vascular smooth muscle cell cellularity within the aorta compared with wild-type mice
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• at E18.5, mice exhibit increased vascular smooth muscle cell (VSMC) proliferation in the aorta compared with wild-type mice
• cultured aorta release >4-fold more VSMCs due to increased proliferation compared with wild-type cultures
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• reduced vessel density
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• reduced vessel density
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• at E18.5, mice exhibit increased vascular smooth muscle cell (VSMC) proliferation in the aorta compared with wild-type mice
• cultured aorta release >4-fold more VSMCs due to increased proliferation compared with wild-type cultures
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit no distinguishable phenotype
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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