Phenotypes associated with this allele

• Allele Symbol: Nlrx1^tm1Jpyt
• Allele Name: targeted mutation 1, Jenny P Y Ting
• Allele ID: MGI:5141085
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlrx1^tm1Jpyt/Nlrx1^tm1Jpyt	involves: C57BL/6 * C57BL/6J	MGI:5141098

Genotype
MGI:5141098

hm1

• Allelic Composition: Nlrx1^tm1Jpyt/Nlrx1^tm1Jpyt
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal neutrophil physiology ( J:173995 )

• neutrophils exhibit a reduction in basal and Pam3Cys-stimulated reactive oxygen species compared with wild-type cells

abnormal macrophage physiology ( J:173995 )

• macrophages exhibit a reduction in basal reactive oxygen species compared with wild-type cells

• LPS-stimulated macrophage produce more IFN-beta, IL6, and IL1b compared with wild-type cells

• however, macrophage stimulated with poly(I:C) exhibit normal IL6 production

increased circulating interleukin-6 level ( J:173995 )

• in influenza-infected mice

increased interferon-beta secretion ( J:173995 )

• in fibroblasts transfected with synthetic RNA analog poly(I:C)

• in fibroblasts stimulated with simian virus 5, Sendai virus, vesicular stomatitis virus, and influenza A virus

• in the lungs of mice infected with influenza virus for 6 days

• however, production in fibroblasts stimulated with encephalomyocarditis virus is normal

• in macrophages stimulated with LPS

increased interleukin-1 beta secretion ( J:173995 )

• in LPS-stimulated macrophage

increased interleukin-6 secretion ( J:173995 )

• in mouse embryonic fibroblasts stimulated with simian virus 5, Sendai virus, and vesicular stomatitis virus

• in LPS-stimulated macrophage and mice

• in the lungs of mice infected with influenza virus

• however, macrophage stimulated with poly(I:C) exhibit normal IL6 production

increased susceptibility to endotoxin shock ( J:173995 )

• LPS-treated mice exhibit increased IL6 production and lung inflammation compared with similarly treated wild-type mice

increased susceptibility to Orthomyxoviridae infection ( J:173995 )

• influenza-infected mice exhibit enhanced viral clearance but increased weight loss lung pathology, IL6 serum levels, and lung levels of IL6 and IFNbeta compared with similarly treated wild-type mice

homeostasis/metabolism

increased circulating interleukin-6 level ( J:173995 )

• in influenza-infected mice

growth/size/body

decreased body weight ( J:173995 )

• in influenza-infected mice

hematopoietic system

abnormal neutrophil physiology ( J:173995 )

• neutrophils exhibit a reduction in basal and Pam3Cys-stimulated reactive oxygen species compared with wild-type cells

abnormal macrophage physiology ( J:173995 )

• macrophages exhibit a reduction in basal reactive oxygen species compared with wild-type cells

• LPS-stimulated macrophage produce more IFN-beta, IL6, and IL1b compared with wild-type cells

• however, macrophage stimulated with poly(I:C) exhibit normal IL6 production