Phenotypes associated with this allele

• Allele Symbol: Tspyl2^tm1Sich
• Allele Name: targeted mutation 1, Siu Yuen Chan
• Allele ID: MGI:5141121
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tspyl2^tm1Sich/Tspyl2^tm1Sich	involves: 129S/SvEv	MGI:5141130
ot2	Tspyl2^tm1Sich/Y	involves: 129S/SvEv	MGI:5141129

Genotype
MGI:5141130

hm1

• Allelic Composition: Tspyl2^tm1Sich/Tspyl2^tm1Sich
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:174549 )

♀N • cultured ES cells, MEFs and thymocytes all show normal proliferation and senescence

♀N • ionizing radiation induce cell death of cultured thymocytes and MEFs is similar to wild-type cells

abnormal cell cycle checkpoint function ( J:174549 )

♀ • following exposure to 10 Gy ionizing radiation MEFs return to S phase more rapidly indicating a defect in maintenance of the G1 checkpoint

♀ • however, checkpoint initiation is similar to wild-type cells and in the absence of treatment no defects in cell cycle are detected

mortality/aging

mortality/aging ( J:174549 )

♀N • normal lifespan

nervous system

nervous system phenotype ( J:174549 )

♀N • no decrease in proliferation of neuronal precursors in the dentate gyrus of the hippocampus or subependyma surrounding the lateral ventricles is detected

♀N • brain morphology is normal

reproductive system

reproductive system phenotype ( J:174549 )

♀N • despite high expression of the gene in wild-type gonads, mice are fertile

neoplasm

neoplasm ( J:174549 )

♀N • no spontaneous tumor formation

Genotype
MGI:5141129

ot2

• Allelic Composition: Tspyl2^tm1Sich/Y
• Genetic Background: involves: 129S/SvEv

cellular

cellular phenotype ( J:174549 )

♂N • cultured ES cells, MEFs and thymocytes all show normal proliferation and senescence

♂N • ionizing radiation induce cell death of cultured thymocytes and MEFs is similar to wild-type cells

abnormal cell cycle checkpoint function ( J:174549 )

♂ • following exposure to 10 Gy ionizing radiation MEFs return to S phase more rapidly indicating a defect in maintenance of the G1 checkpoint

♂ • however, checkpoint initiation is similar to wild-type cells and in the absence of treatment no defects in cell cycle are detected

mortality/aging

mortality/aging ( J:174549 )

♂N • normal lifespan

nervous system

nervous system phenotype ( J:174549 )

♂N • no decrease in proliferation of neuronal precursors in the dentate gyrus of the hippocampus or subependyma surrounding the lateral ventricles is detected

♂N • brain morphology is normal

reproductive system

reproductive system phenotype ( J:174549 )

♂N • despite high expression of the gene in wild-type gonads, mice are fertile

neoplasm

neoplasm ( J:174549 )

♂N • no spontaneous tumor formation