All Phenotypes Slc17a6<tm2(cre)Lowl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc17a6^tm2(cre)Lowl
targeted mutation 2, Bradford B Lowell
MGI:5141269

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rai1^tm2.1Luo/Rai1^tm2.1Luo Slc17a6^tm2(cre)Lowl/?	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)	MGI:5817637
cn2	Rai1^tm2.1Luo/Rai1⁺ Slc17a6^tm2(cre)Lowl/?	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)	MGI:5817641
cn3	Mc4r^tm2Lowl/Mc4r^tm2Lowl Slc17a6^tm2(cre)Lowl/Slc17a6⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5609673
cn4	Mc4r^tm1Lowl/Mc4r^tm1Lowl Slc17a6^tm2(cre)Lowl/Slc17a6⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5609677
cn5	Lepr^tm1.1Chua/Lepr^tm1.1Chua Slc17a6^tm2(cre)Lowl/Slc17a6⁺	involves: 129S6/SvEvTac	MGI:5142145

Allelic Composition	Rai1^tm2.1Luo/Rai1^tm2.1Luo Slc17a6^tm2(cre)Lowl/?
Genetic Background	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Slc17a6^tm2(cre)Lowl mutation (3 available); any Slc17a6 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal associative learning ( J:237687 )

impaired contextual conditioning behavior ( J:237687 )

• decreased freezing behavior in contextual recall in trace fear-conditioning task

impaired cued conditioning behavior ( J:237687 )

• decreased freezing behavior in cued recall

impaired coordination ( J:237687 )

• increased time required to descend in pole test

• increased latency to fall in wire hang test

growth/size/body

obese ( J:237687 )

• males and females become obese at 9 and 7 weeks, respectively and are 56% (males) and 116% (females) heavier than controls at 20 weeks

Allelic Composition	Rai1^tm2.1Luo/Rai1⁺ Slc17a6^tm2(cre)Lowl/?
Genetic Background	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:237687 )

• increased latency to fall in wire hang test

growth/size/body

increased body weight ( J:237687 )

• males and females exhibit 16% and 29% (respectively ) increased body weight as compared to controls

Allelic Composition	Mc4r^tm2Lowl/Mc4r^tm2Lowl Slc17a6^tm2(cre)Lowl/Slc17a6⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4r^tm2Lowl mutation (0 available); any Mc4r mutation (48 available)
Slc17a6^tm2(cre)Lowl mutation (3 available); any Slc17a6 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:216397 )

• increased fat mass

behavior/neurological

polyphagia ( J:216397 )

growth/size/body

obese ( J:216397 )

increased body length ( J:216397 )

Allelic Composition	Mc4r^tm1Lowl/Mc4r^tm1Lowl Slc17a6^tm2(cre)Lowl/Slc17a6⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4r^tm1Lowl mutation (2 available); any Mc4r mutation (48 available)
Slc17a6^tm2(cre)Lowl mutation (3 available); any Slc17a6 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:216397 )

N	• rescue of the increased weight gain, of the fat stores, of hyperphagia and of the increased linear length seen in single Mc4r homozygotes

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:216397 )

N	• mice show normalization of the hyperglycemia and hyperinsulinemia that is seen in single Mc4r homozygotes

respiratory system

respiratory system phenotype ( J:216397 )

N	• rescue of the depressed respiratory exchange ratio seen in single Mc4r homozygotes

Allelic Composition	Lepr^tm1.1Chua/Lepr^tm1.1Chua Slc17a6^tm2(cre)Lowl/Slc17a6⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^tm1.1Chua mutation (1 available); any Lepr mutation (122 available)
Slc17a6^tm2(cre)Lowl mutation (3 available); any Slc17a6 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:174691 )

N	• animals do not show significant changes in body weight up to 11 weeks of age

behavior/neurological

behavior/neurological phenotype ( J:174691 )

N	• food intake shows no significant difference compared to controls

nervous system

nervous system phenotype ( J:174691 )

N	• deletion of Lepr in Slc17a6 neurons does not alter IPSC amplitude in Agrp neurons; IPSC frequency is decreased (not significantly) in Agrp • excitatory postsynaptic currents (sEPSCs and mEPSCs) in Pomc1 neurons are not affected by Lepr deletion in Slc17a6 (glutamatergic) neurons

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:174691 )

N	• fed and fasted blood glucose levels are unchanged and serum insulin levels are only slightly increased in the fed state

adipose tissue

adipose tissue phenotype ( J:174691 )

N	• no increase in fat mass is observed at 10 weeks

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