Phenotypes associated with this allele

• Allele Symbol: Gata4^tm1.1Jmol
• Allele Name: targeted mutation 1.1, Jeffery D Molkentin
• Allele ID: MGI:5141274
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata4^tm1.1Jmol/Gata4^tm1.1Jmol	involves: 129 * C57BL/6	MGI:5141275
cx2	Gata4^tm1.1Jmol/Gata4^tm1.1Jmol Tg(Myh6-Map2k1*)1Jmol/0	involves: 129 * C57BL/6 * FVB	MGI:5141280

Genotype
MGI:5141275

hm1

• Allelic Composition: Gata4^tm1.1Jmol/Gata4^tm1.1Jmol
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart ventricle morphology ( J:174537 )

• heart ventricular weight normalized to body weight is slightly but significantly decreased at 8 weeks of age

abnormal response of heart to induced stress ( J:174537 )

• after 2 weeks of transverse aortic constriction induced pressure overload, left ventricular dilation and reduced fractional shortening are seen suggesting cardiac failure with dilation

• after 2 weeks of pressure overload cardiomyocytes show signs of eccentric remodeling and enhanced fibrosis

decreased response of heart to induced stress ( J:174537 )

• the hypertrophic response induced by prolonged (2 week) exposure to phenylephrine is significantly blunted

• the hypertrophic response to 1 week of pressure overload is significantly blunted

endocrine/exocrine glands

decreased seminal vesicle weight ( J:308912 )

♂ • in adult mice

homeostasis/metabolism

abnormal response of heart to induced stress ( J:174537 )

• after 2 weeks of transverse aortic constriction induced pressure overload, left ventricular dilation and reduced fractional shortening are seen suggesting cardiac failure with dilation

• after 2 weeks of pressure overload cardiomyocytes show signs of eccentric remodeling and enhanced fibrosis

decreased response of heart to induced stress ( J:174537 )

• the hypertrophic response induced by prolonged (2 week) exposure to phenylephrine is significantly blunted

• the hypertrophic response to 1 week of pressure overload is significantly blunted

decreased circulating testosterone level ( J:308912 )

♂ • in adult mice

reproductive system

decreased seminal vesicle weight ( J:308912 )

♂ • in adult mice

Genotype
MGI:5141280

cx2

• Allelic Composition: Gata4^tm1.1Jmol/Gata4^tm1.1Jmol; Tg(Myh6-Map2k1*)1Jmol/0
• Genetic Background: involves: 129 * C57BL/6 * FVB

cardiovascular system

abnormal heart size ( J:174537 )

• hypertrophy is markedly attenuated compared to transgenic mice wild-type for Gata4