Analysis Tools
nervous system
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• central nervous system nodes of Ranvier remain intact after tamoxifen treatment
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• Purkinje cells from tamoxifen-treated mice exhibit axon initial segment disintegration compared with control mice
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• after 16 weeks, Purkinje cells from tamoxifen-treated mice lack pinceau synapses or exhibit reduced pinceau synapse size compared with control mice
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• Purkinje cells tamoxifen-treated mice require a greater current to drive spike firing compared with control mice
• wave-form of action potential exhibit reduced maximum rate of rise and peak amplitude and increased half-width and delay until peak of the afterhyperpolarization potential compared to in control cells
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• Purkinje cells of tamoxifen-treated mice fail to maintain spontaneous action potential firing and instead maintain a modal resting potential compared with control cells
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behavior/neurological
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• at 6 weeks, tamoxifen-treated mice exhibit impaired performance and balance on a rotarod compared with wild-type mice
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• at 6 weeks, tamoxifen-treated mice exhibit impaired performance and balance on a rotarod compared with wild-type mice
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• in tamoxifen-treated mice at 6 weeks
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