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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cav1tm1.1Aia
targeted mutation 1.1, Alexander I Agoulnik
MGI:5141474
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cav1tm1.1Aia/Cav1tm1.1Aia involves: 129S7/SvEvBrd * C57BL/6J MGI:5141497
cx2
 		Cav1tm1.1Aia/Cav1tm1.1Aia
crsp/crsp 		involves: 129S7/SvEvBrd * C57BL/6J * FVB MGI:5141498
cx3
 		Cav1tm1.1Aia/Cav1tm1.1Aia
crsp/+ 		involves: 129S7/SvEvBrd * C57BL/6J * FVB MGI:5141500
cx4
 		Cav1tm1.1Aia/Cav1tm1.1Aia
Rxfp2tm1Aia/Rxfp2+ 		involves: 129S7/SvEvBrd * C57BL/6J * FVB MGI:5141501


Genotype
MGI:5141497
hm1
Allelic
Composition		 Cav1tm1.1Aia/Cav1tm1.1Aia
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cav1tm1.1Aia mutation (0 available); any Cav1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:174719 )
N
• mice are fertile
increased endometrial gland number ( J:174719 )
• mice exhibit an increase in the number of endometrial glands compared with wild-type mice
ovary cyst ( J:174719 )
• in 6% of mice
uterus cyst ( J:174719 )
• in 19% of mice
abnormal uterus physiology ( J:174719 )
• endometrial glandular epithelium in mice with cysts exhibit increased proliferation compared to in wild-type mice

neoplasm
neoplasm ( J:174719 )
N
• mice do not develop endometrial cancer or metastases

endocrine/exocrine glands
increased endometrial gland number ( J:174719 )
• mice exhibit an increase in the number of endometrial glands compared with wild-type mice
ovary cyst ( J:174719 )
• in 6% of mice

growth/size/body
ovary cyst ( J:174719 )
• in 6% of mice
uterus cyst ( J:174719 )
• in 19% of mice




Genotype
MGI:5141498
cx2
Allelic
Composition		 Cav1tm1.1Aia/Cav1tm1.1Aia
crsp/crsp
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cav1tm1.1Aia mutation (0 available); any Cav1 mutation (31 available)
crsp mutation (0 available); any crsp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased endometrial gland number ( J:174719 )
• mice exhibit an increase in the number of endometrial glands compared with wild-type mice
ovary cyst ( J:174719 )
• in 8% of mice
uterus cyst ( J:174719 )
• in 62% of mice

neoplasm
neoplasm ( J:174719 )
N
• mice do not develop endometrial cancer or metastases

endocrine/exocrine glands
increased endometrial gland number ( J:174719 )
• mice exhibit an increase in the number of endometrial glands compared with wild-type mice
ovary cyst ( J:174719 )
• in 8% of mice

growth/size/body
ovary cyst ( J:174719 )
• in 8% of mice
uterus cyst ( J:174719 )
• in 62% of mice




Genotype
MGI:5141500
cx3
Allelic
Composition		 Cav1tm1.1Aia/Cav1tm1.1Aia
crsp/+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cav1tm1.1Aia mutation (0 available); any Cav1 mutation (31 available)
crsp mutation (0 available); any crsp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:174719 )
N
• female mice are fertile
increased endometrial gland number ( J:174719 )
• mice exhibit an increase in the number of endometrial glands compared with wild-type mice
ovary cyst ( J:174719 )
• in 4% of mice
uterus cyst ( J:174719 )
• in 55% of mice

neoplasm
neoplasm ( J:174719 )
N
• mice do not develop endometrial cancer or metastases

endocrine/exocrine glands
increased endometrial gland number ( J:174719 )
• mice exhibit an increase in the number of endometrial glands compared with wild-type mice
ovary cyst ( J:174719 )
• in 4% of mice

growth/size/body
ovary cyst ( J:174719 )
• in 4% of mice
uterus cyst ( J:174719 )
• in 55% of mice




Genotype
MGI:5141501
cx4
Allelic
Composition		 Cav1tm1.1Aia/Cav1tm1.1Aia
Rxfp2tm1Aia/Rxfp2+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cav1tm1.1Aia mutation (0 available); any Cav1 mutation (31 available)
Rxfp2tm1Aia mutation (0 available); any Rxfp2 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:174719 )
N
• female mice are fertile
increased endometrial gland number ( J:174719 )
• mice exhibit an increase in the number of endometrial glands compared with wild-type mice
ovary cyst ( J:174719 )
• in 6% of mice at 11 to 13 months
uterus cyst ( J:174719 )
• in 58% of mice at 11 to 13 months
• in 24% of mice at 5 to 7 months
abnormal uterus physiology ( J:174719 )
• endometrial glandular epithelium in mice with cysts exhibit increased proliferation compared to in wild-type mice

neoplasm
neoplasm ( J:174719 )
N
• mice do not develop endometrial cancer or metastases

endocrine/exocrine glands
increased endometrial gland number ( J:174719 )
• mice exhibit an increase in the number of endometrial glands compared with wild-type mice
ovary cyst ( J:174719 )
• in 6% of mice at 11 to 13 months

growth/size/body
ovary cyst ( J:174719 )
• in 6% of mice at 11 to 13 months
uterus cyst ( J:174719 )
• in 24% of mice at 5 to 7 months
• in 58% of mice at 11 to 13 months




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory