Analysis Tools
muscle
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• 42% reduction in muscle connective tissue fibroblasts after 5 doses of tamoxifen
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• ablation of fibroblasts leads to 51% reduction in muscle satellite cells 5 days post injury
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• at 3 days post injury fibroblasts are reduced 19% but myofiber regeneration is increased 5 fold
• leads to depletion of satellite cell pool and reduction in regenerating myofibers at 5 days
• tibialis anterior muscle is regenerated at 28 days after injury but somewhat smaller in cross-sectional area
• satellite cell numbers have recovered after 28 days
• smaller diameter of regenerated myofibers
• muscle size differences are no longer significant at 56 days after injury
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